CD45 anticorps (FITC)
-
- Antigène Voir toutes CD45 (PTPRC) Anticorps
- CD45 (PTPRC) (Protein tyrosine Phosphatase, Receptor Type, C (PTPRC))
-
Reactivité
- Humain, Souris, Cat
-
Hôte
- Rat
-
Clonalité
- Monoclonal
-
Conjugué
- Cet anticorp CD45 est conjugé à/à la FITC
-
Application
- Flow Cytometry (FACS)
- Specificité
- The rat monoclonal antibody RA3-6B2 recognizes an extracellular epitope on CD45R, which is expressed at all developmental stages of B cells, including activated B cells, but also on subsets of NK and T cells. T cells detected by this antibody are supposed to be in activated state.
- Réactivité croisée (Details)
- Human, Mouse, Feline (Cat)
- Purification
- Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- Immunogène
- Abelson murine leukemia virus-induced pre-B tumor cells
- Clone
- RA3-6B2
- Isotype
- IgG2a kappa
- Top Product
- Discover our top product PTPRC Anticorps primaire
-
-
- Indications d'application
- Flow cytometry: Recommended dilution: 1-4 μg/mL.
- Commentaires
-
The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC.
- Restrictions
- For Research Use only
-
- Concentration
- 0.5 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
-
Do not freeze.
Avoid prolonged exposure to light. - Stock
- 4 °C
- Stockage commentaire
- Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
-
-
Endothelial cells and fibroblasts amplify the arthritogenic type I IFN response in murine Lyme disease and are major sources of chemokines in Borrelia burgdorferi-infected joint tissue." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 189, Issue 5, pp. 2488-501, (2012) (PubMed).
: "Identification of a B-1 B cell-specified progenitor." dans: Nature immunology, Vol. 7, Issue 3, pp. 293-301, (2006) (PubMed).
: "Evaluation of intranuclear BrdU detection procedures for use in multicolor flow cytometry." dans: Cytometry. Part A : the journal of the International Society for Analytical Cytology, Vol. 69, Issue 4, pp. 249-59, (2006) (PubMed).
: "Lupus IgG VH4.34 antibodies bind to a 220-kDa glycoform of CD45/B220 on the surface of human B lymphocytes." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 7, pp. 4298-307, (2004) (PubMed).
: "Seven-color fluorescence imaging of tissue samples based on Fourier spectroscopy and singular value decomposition." dans: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 48, Issue 5, pp. 653-62, (2000) (PubMed).
: "Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting." dans: Immunity, Vol. 9, Issue 1, pp. 135-41, (1998) (PubMed).
: "Activation signal induces the expression of B cell-specific CD45R epitope (6B2) on murine T cells." dans: Scandinavian journal of immunology, Vol. 39, Issue 5, pp. 419-25, (1994) (PubMed).
: "
-
Endothelial cells and fibroblasts amplify the arthritogenic type I IFN response in murine Lyme disease and are major sources of chemokines in Borrelia burgdorferi-infected joint tissue." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 189, Issue 5, pp. 2488-501, (2012) (PubMed).
-
- Antigène
- CD45 (PTPRC) (Protein tyrosine Phosphatase, Receptor Type, C (PTPRC))
- Autre désignation
- CD45R (PTPRC Produits)
- Synonymes
- anticorps PTPRC, anticorps si:dkeyp-47c5.1, anticorps B220, anticorps CD45, anticorps CD45R, anticorps GP180, anticorps L-CA, anticorps LCA, anticorps LY5, anticorps T200, anticorps Cd45, anticorps Ly-5, anticorps Lyt-4, anticorps loc, anticorps Lca, anticorps RT7, anticorps cd45, anticorps protein tyrosine phosphatase, receptor type C, anticorps protein tyrosine phosphatase, receptor type, C, anticorps receptor-type tyrosine-protein phosphatase C, anticorps PTPRC, anticorps ptprc, anticorps LOC100074271, anticorps Ptprc
- Sujet
- CD45R, also known as B220, is a receptor-type protein tyrosine phosphatase glycoprotein. It is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45R expression also identifies a subset of murine bone marrow cells able to form osteoclast-like cells.,PTPRCR, T200R
- Pathways
- TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, CXCR4-mediated Signaling Events, BCR Signaling
-