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PIK3CA anticorps (C-Term)

PIK3CA Reactivité: Humain WB, IHC (p), FACS Hôte: Lapin Polyclonal RB01702 unconjugated
N° du produit ABIN1882113
  • Antigène Voir toutes PIK3CA Anticorps
    PIK3CA (Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA))
    Épitope
    • 15
    • 15
    • 13
    • 11
    • 9
    • 7
    • 7
    • 7
    • 6
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1019-1050, C-Term
    Reactivité
    • 87
    • 60
    • 32
    • 25
    • 15
    • 3
    • 2
    Humain
    Hôte
    • 87
    • 8
    • 2
    • 1
    Lapin
    Clonalité
    • 83
    • 15
    Polyclonal
    Conjugué
    • 32
    • 9
    • 8
    • 7
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp PIK3CA est non-conjugé
    Application
    • 77
    • 38
    • 32
    • 26
    • 26
    • 11
    • 6
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)
    Homologie
    B
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogène
    This PI3KCA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1019-1050 amino acids from the C-terminal region of human PI3KCA.
    Clone
    RB01702
    Isotype
    Ig Fraction
    Top Product
    Discover our top product PIK3CA Anticorps primaire
  • Indications d'application
    WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid freeze-thaw cycles.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.
    Date de péremption
    6 months
  • Zhai, Zhao, Ye, Huang, Tian, Wu, Lin, Lin: "Expression of PIK3CA and FOXP1 in gastric and intestinal non-Hodgkin's lymphoma of mucosa-associated lymphoid tissue type." dans: Tumour biology, Vol. 32, Issue 5, pp. 913-20, (2011) (PubMed).

    Tiwari, Choi, Matsuzawa, Pypaert, MacMicking: "Targeting of the GTPase Irgm1 to the phagosomal membrane via PtdIns(3,4)P(2) and PtdIns(3,4,5)P(3) promotes immunity to mycobacteria." dans: Nature immunology, Vol. 10, Issue 8, pp. 907-17, (2009) (PubMed).

    Singh, Reddy, Goberdhan, Walsh, Dao, Ngai, Chou, O-Charoenrat, Levine, Rao, Stoffel: "p53 regulates cell survival by inhibiting PIK3CA in squamous cell carcinomas." dans: Genes & development, Vol. 16, Issue 8, pp. 984-93, (2002) (PubMed).

  • Antigène
    PIK3CA (Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA))
    Autre désignation
    PI3KCA (PIK3CA Produits)
    Synonymes
    anticorps CLOVE, anticorps CWS5, anticorps MCAP, anticorps MCM, anticorps MCMTC, anticorps PI3K, anticorps p110-alpha, anticorps C-P3K, anticorps PI3-kinase, anticorps PI3K-alpha, anticorps pi3-k, anticorps pi3k, anticorps AA414921, anticorps C530050K14, anticorps p50alpha, anticorps p55alpha, anticorps p85alpha, anticorps 6330412C24Rik, anticorps caPI3K, anticorps p110, anticorps p110alpha, anticorps phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha, anticorps Phosphoinositide-3-kinase, catalytic, alpha polypeptide, anticorps phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, anticorps phosphoinositide-3-kinase regulatory subunit 1, anticorps PIK3CA, anticorps GL50803_14855, anticorps pik3ca, anticorps Pik3ca, anticorps Pik3r1
    Sujet
    Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. This protein represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. PI3KCA has been found to be oncogenic and has been implicated in cervical cancers.
    Poids moléculaire
    124284
    NCBI Accession
    NP_006209
    UniProt
    P42336
    Pathways
    Signalisation PI3K-Akt, Signalisation RTK, TCR Signaling, AMPK Signaling, Interferon-gamma Pathway, Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Inositol Metabolic Process, Hepatitis C, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals, VEGF Signaling
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