Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

GSAP anticorps (C-Term)

PION Reactivité: Humain, Rat, Souris WB, IHC, ELISA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN1887280
  • Antigène Voir toutes GSAP (PION) Anticorps
    GSAP (PION) (Pigeon Homolog (PION))
    Épitope
    • 8
    • 6
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 16
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    Humain, Rat, Souris
    Hôte
    • 16
    • 2
    • 1
    Lapin
    Clonalité
    • 18
    • 1
    Polyclonal
    Conjugué
    • 11
    • 2
    • 2
    • 2
    • 1
    • 1
    Cet anticorp GSAP est non-conjugé
    Application
    • 19
    • 13
    • 10
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA
    Réactivité croisée (Details)
    Multiple isoforms of PION are known to exist. PION antibody is predicted to not cross-react with other F-box protein family members.
    Purification
    Affinity chromatography purified via peptide column
    Immunogène
    19 amino acid peptide near the carboxy terminus of human PION.
    Top Product
    Discover our top product PION Anticorps primaire
  • Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS containing 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
    Conseil sur la manipulation
    Avoid freezing and thawing repeatly.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store at 4 °C for short term use.Store at -20 °C for long term preservation.
  • Antigène
    GSAP (PION) (Pigeon Homolog (PION))
    Abstract
    PION Produits
    Synonymes
    anticorps PION, anticorps A530088I07Rik, anticorps Pion, anticorps gamma-secretase activating protein, anticorps GSAP, anticorps Gsap
    Sujet
    Accumulation of the amyloid-beta peptide (Abeta) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease.The beta?amyloid protein precursor (APP) is cleaved by one of two beta?secretases (BACE and BACE2), producing a soluble derivative of the protein and a membrane anchored 99 -amino acid carboxy-terminal fragment (C99).The C99 fragment serves as substrate for gamma?secretase to generate the 4 kDa amyloid-beta peptide (Abeta), which is deposited in the Alzheimer's disease patients' brains.PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and the APP C-terminal fragment, suggesting that PION may be a potential therapeutic target for the treatment of Alzheimer's disease.
    Synonyms: Protein pigeon homolog, gamma-secretase activating protein, GSAP
    NCBI Accession
    NP_059135
Vous êtes ici:
Support technique