MAVS anticorps (Center)

N° du produit ABIN1887647

Détail du produit anti-MAVS anticorps

Antigène: MAVS (Mitochondrial Antiviral Signaling Protein (MAVS))

Épitope: Center

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAVS est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Affinity chromatography purified via peptide column

Immunogène: 17 amino acid peptide from near the center of human VISA.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur MAVS

Antigène: MAVS (Mitochondrial Antiviral Signaling Protein (MAVS))

Autre désignation: VISA (MAVS Produits)

Synonymes: anticorps CARDIF, anticorps IPS-1, anticorps IPS1, anticorps VISA, anticorps D430028G21Rik, anticorps Visa, anticorps cardif, anticorps wu:fj20d04, anticorps zgc:158392, anticorps mitochondrial antiviral signaling protein, anticorps MAVS, anticorps Mavs, anticorps mavs

Sujet: Two distinct signaling pathways activate the host innate immunity against viral infection.One pathway is reliant on members of the Toll-like receptor (TLR) family while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA as a trigger for the immune response.VISA is a mitochondrial membrane protein that was identified as a critical component in the IFN-b signaling pathways that recruits IRF-3 to RIG-I, leading to its activation and that of NF-kappaB.VISA is also thought to interact with other components of the innate immune pathway such as the TLR adapter protein TRIF, TRAF2 and TRAF6.VISA also interacts with the IKKalpha, IKKbeta and IKKepsilon kinases through its C-terminal region.Cleavage of this region by the Hepatitis C virus (HCV) protease allows HCV to escape the host immune system.At least three isoforms of VISA are known to exist.
Synonyms: Virus-induced signaling adapter, mitochondrial antiviral signaling protein, MAVS, CARD adapter inducing interferon-beta, Cardif, IPS-1

NCBI Accession: NP_065797

Pathways: Activation of Innate immune Response, Inositol Metabolic Process, Hepatitis C