THEM4 anticorps (Center)

N° du produit ABIN1887790

Détail du produit anti-THEM4 anticorps

Antigène: THEM4 (Thioesterase Superfamily Member 4 (THEM4))

Épitope: Center

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp THEM4 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificité: The additional higher molecular weight bands seen in the immunoblot may represent post-translationally modified TMEM4.

Purification: Affinity chromatography purified via peptide column

Immunogène: THEM4 antibody was raised against an 18 amino acid peptide near the center of human THEM4.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur THEM4

Antigène: THEM4 (Thioesterase Superfamily Member 4 (THEM4))

Autre désignation: THEM4 (THEM4 Produits)

Synonymes: anticorps THEM4, anticorps CTMP, anticorps 2700077M13Rik, anticorps 4921507I02Rik, anticorps RGD1304723, anticorps thioesterase superfamily member 4, anticorps thioesterase superfamily member 4 L homeolog, anticorps THEM4, anticorps them4, anticorps Them4, anticorps them4.L

Sujet: THEM4, also known as CTMP, binds specifically to the carboxy-terminal regulatory domain of PKB/Akt at the plasma membrane and acts as a negative regulator, reversing the phenotype of v-Akt-transformed cells.Hypermethylation of the THEM4 promoter and transcriptional downregulation of the gene has been reported in multiple glioblastomas, suggesting that epigenetic regulation of THEM4 may play a role in the progression of this cancer.Bioinformatic analysis, confirmed by in vitro testing, indicates that THEM4 is a broad-range, high activity acyl-CoA thioesterase.Recent reports have also indicated that TMEM4 is a mitochondrial protein whose overexpression is associated with an increase in mitochondrial membrane depolarization and caspase-3 and PARP cleavage, suggesting that THEM4 is involved in the apoptotic program.
Synonyms: Thioesterase superfamily member 4, Carboxy-terminal modulator protein, CTMP

NCBI Accession: NP_444283

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway