Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 (NGFRAP1) (Middle Region) anticorps

N° du produit ABIN1887809

Détail du produit

Antigène: Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 (NGFRAP1)

Épitope: Middle Region

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Purification: Ion exchange chromatography purified

Immunogène: Peptide corresponding to 14 amino acids near the middle of human NADE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détail du antigène

Antigène: Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 (NGFRAP1)

Autre désignation: NADE (NGFRAP1 Produits)

Synonymes: anticorps BEX3, anticorps Bex, anticorps DXS6984E, anticorps HGR74, anticorps NADE, anticorps NGFRAP1, anticorps LNGFR, anticorps Tnfrsf16, anticorps p75, anticorps p75NGFR, anticorps p75NTR, anticorps AL033356, anticorps Bex3, anticorps DXWsu67e, anticorps Gcap27, anticorps Nade, anticorps WBP5, anticorps brain expressed X-linked 3, anticorps nerve growth factor receptor (TNFR superfamily, member 16), anticorps BEX3, anticorps Ngfr, anticorps Bex3

Sujet: The p75 neurotrophin receptor (p75NTR) is a member of the tumor necrosis receptor superfamily and can mediate cell death and cell survival in response to nerve growth factor (NGF).The p75NTR-associated cell death executor (NADE) mediates apoptosis by interacting with the cell death domain of p75NTR following the binding of NGF by p75NTR.Recent studies have shown that NADE also interacts with second mitochondria-derived activator of caspase (Smac).Co-expression of NADE and Smac promotes TRAIL-induced apoptosis and inhibits XIAP-mediated Smac ubiquitization.It has been suggested that it is this interaction between NADE and Smac that allows apoptosis to proceed.Finally, although initially discovered as an mRNA expressed in ovarian granulosa cells, NADE has been suggested to play a role in the neuronal death seen in epileptic brain damage.

NCBI Accession: NP_996798

Pathways: Neurotrophin Signaling Pathway, Positive Regulation of Endopeptidase Activity