CCR3 anticorps (N-Term)

N° du produit ABIN1887854

Détail du produit anti-CCR3 anticorps

Antigène: CCR3 (Chemokine (C-C Motif) Receptor 3 (CCR3))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CCR3 est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: Immunoaffinity purified IgG

Immunogène: 14 amino acid peptide from near the amino terminus of human CCR3.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur CCR3

Antigène: CCR3 (Chemokine (C-C Motif) Receptor 3 (CCR3))

Autre désignation: CCR3 (CCR3 Produits)

Synonymes: anticorps CC-CKR-3, anticorps CD193, anticorps CKR3, anticorps CMKBR3, anticorps CC-CKR3, anticorps Cmkbr1l2, anticorps Cmkbr3, anticorps C-C motif chemokine receptor 3, anticorps chemokine (C-C motif) receptor 3, anticorps CCR3, anticorps Ccr3

Sujet: Human immunodeficiency virus (HIV) and related virus require coreceptors to infect target cells.Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b, CCR8, GPR15, STRL33, and CX3CR1 in the chemokine receptor family were recently identified as HIV coreceptors.CCR5, CXCR4 and CCR3 are the principal receptors for HIV fusion and entry of target cells.CCR3 facilitates infection by a subset of virus.CCR3 and CCR5 promote efficient infection of microglia, the major target cells in the CNS.High levels of CCR3 and CXCR4 expression were found on the neurons from both the central and peripheral nervous systems.The CCR3 ligand, eotaxin, and an anti-CCR3 antibody inhibited HIV infection of microglia.These results indicate CCR3 plays an important role in HIV infection of CNS.
Synonyms: CC chemokine receptor 3, eosinophil eotaxin receptor

NCBI Accession: NP_847899