USP5 anticorps

N° du produit ABIN1944895

Détail du produit anti-USP5 anticorps

Antigène: USP5 (Ubiquitin Specific Peptidase 5 (USP5))

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp USP5 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogène: This USP5 antibody is generated from a mouse immunized with a recombination protein from the human region of human USP5.

Clone: 1340CT704-170-140

Isotype: IgG1 kappa

Information d'application

Indications d'application: WB: 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-USP5 (ABIN1944895)

Falquet, Paquet, Frutiger, Hughes, Hoang-Van, Jaton: "cDNA cloning of a human 100 kDa de-ubiquitinating enzyme: the 100 kDa human de-ubiquitinase belongs to the ubiquitin C-terminal hydrolase family 2 (UCH2)." dans: FEBS letters, Vol. 376, Issue 3, pp. 233-7, (1996) (PubMed).

Détails sur USP5

Antigène: USP5 (Ubiquitin Specific Peptidase 5 (USP5))

Autre désignation: USP5 (USP5 Produits)

Synonymes: anticorps ISOT, anticorps AA407472, anticorps ISOT-1, anticorps Ucht, anticorps ubiquitin specific peptidase 5, anticorps ubiquitin carboxyl-terminal hydrolase 5, anticorps ubiquitin carboxyl-terminal hydrolase 5, putative, anticorps ubiquitin specific protease 5, anticorps ubiquitin specific peptidase 5 (isopeptidase T), anticorps USP5, anticorps CNH02890, anticorps EHI_049940, anticorps CC1G_12961, anticorps MCYG_01862, anticorps CGB_L3600C, anticorps PY00546, anticorps Usp5

Sujet: Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys- 63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.

Poids moléculaire: 95786

ID gène: 8078

UniProt: P45974