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PPP1R13B anticorps (Internal Region)

PPP1R13B Reactivité: Humain ELISA, WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN233830
$658.50
Plus frais de port $45.00 et $20.00 pour carboglace
100 μg
Destination: Etats-Unis
Envoi sous 1 à 2 jours ouvrables
  • Antigène Voir toutes PPP1R13B Anticorps
    PPP1R13B (Protein Phosphatase 1, Regulatory Subunit 13B (PPP1R13B))
    Épitope
    • 15
    • 9
    • 8
    • 8
    • 7
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    • 54
    • 15
    • 7
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 54
    • 1
    Lapin
    Clonalité
    • 54
    • 1
    Polyclonal
    Conjugué
    • 18
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp PPP1R13B est non-conjugé
    Application
    • 30
    • 24
    • 13
    • 13
    • 3
    • 3
    • 3
    • 2
    ELISA, Western Blotting (WB)
    Immunogène
    This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an sequence of human ASPP1.
    Isotype
    IgG
  • Indications d'application
    This affinity purified antibody has been tested for use in ELISA and western blotting. Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 120 kDa in size corresponding to ASPP1 by western blotting in the appropriate cell lysate or extract.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
  • Antigène
    PPP1R13B (Protein Phosphatase 1, Regulatory Subunit 13B (PPP1R13B))
    Autre désignation
    ASPP1 (PPP1R13B Produits)
    Synonymes
    ASPP1, p53BP2-like, p85, AI449786, AW545810, Tp53bp2, Trp53bp2, protein phosphatase 1 regulatory subunit 13B, protein phosphatase 1, regulatory subunit 13B, protein phosphatase 1 regulatory subunit 13B L homeolog, protein phosphatase 1, regulatory subunit 13Bb, protein phosphatase 1, regulatory (inhibitor) subunit 13B, PPP1R13B, Ppp1r13b, ppp1r13b.L, ppp1r13bb, ppp1r13b
    Sujet
    ASPP (ankyrin-repeat-, SH3-domain- proline-rich-region protein) proteins (ASPP1, ASPP2 and iASPP) represent a new family of p53 binding proteins.  ASPP1 and ASPP2 bind and enhance p53-mediated apoptosis.  In contrast, iASPP functionally inactivates p53.  ASPPs may also regulate p63- and p73-mediated apoptosis.  Both ASPP1 and 2 directly interact with p53 and specifically enhance the apoptotic function of p53 by stimulating its DNA binding and transactivation function on promoters of pro-apoptotic genes, such as Bax and PIG-3.  Not all cell cycle arrest genes are affected, such as p21.  Interestingly, expression of ASPP is frequently down-regulated in human breast carcinomas expressing wild-type p53 but not mutant p53.  Therefore, ASPP might regulate the tumor suppression function of p53 in vivo.
    Synonyms: p53BP2 like antibody, p85 antibody, PPP1R13B antibody
    ID gène
    23368, 121114287
    UniProt
    Q62415
    Pathways
    Signalisation p53
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