HLA-DRB1 anticorps

N° du produit ABIN238469

Détail du produit anti-HLA-DRB1 anticorps

Antigène: HLA-DRB1 (Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp HLA-DRB1 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Attributs du produit: Synonyms: MHC class II antigen DRB1, DR1, DR-1, HLA class II histocompatibility antigen, DRB1-1 betachain

Purification: Protein A affinity chromatography.

Immunogène: Purified, insoluble DR1 beta chain (DRB1*0101) expressed in E. coli inclusion bodies.

Clone: MEM-267

Isotype: IgG2b

Information d'application

Indications d'application: Western Blotting. Flow Cytometry: The antibody MEM-267 stains immature dendritic cells that express emptycell surface MHC molecules, but not cells that express predominantly peptide loadedforms. ELISA.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.4 containing 15 mM sodium azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur HLA-DRB1

Antigène: HLA-DRB1 (Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1))

Autre désignation: HLA Class II DR beta 1 / HLA-DRB1 (HLA-DRB1 Produits)

Synonymes: anticorps MGC108235, anticorps DRB1, anticorps DRw10, anticorps HLA-DR1B, anticorps HLA-DRB, anticorps SS1, anticorps major histocompatibility complex, class II, DR beta 1, anticorps hla-drb1, anticorps HLA-DRB1

Sujet: HLA-DR1 belongs to the HLA class II beta chain paralogues. The MHC Class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. MHC Class II molecules are expressed in antigen presenting cells (APC). The beta chain is approximately 26-28 kDa. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation.Synonyms: DR-1, DR1, DRB1-1 beta chain, HLA class II histocompatibility antigen, MHC class II antigen DRB1

UniProt: P04229

Pathways: TCR Signaling, Positive Regulation of Peptide Hormone Secretion, Production of Molecular Mediator of Immune Response, CXCR4-mediated Signaling Events, Cancer Immune Checkpoints