PRNP anticorps

N° du produit ABIN2452081

Détail du produit anti-PRNP anticorps

Antigène: PRNP (Prion Protein (PRNP))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PRNP est non-conjugé

Application: Western Blotting (WB), ELISA

Réactivité croisée (Details): Does not react with mouse Prion. Not tested with other species

Purification: Purified

Stérilité: Sterile filtered

Immunogène: Recombinant human PrP lacking GPI anchor expressed and purified from rabbit kidney cell line RK13.

Clone: 7A1

Isotype: IgG

Information d'application

Indications d'application: 1) Western blotting: ~0. 5 g/mL
2) ELISA
Other applications have not been tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Upon arrival centrifuge briefly, aliquot and store at -20 C

Références pour anticorps anti-PRNP (ABIN2452081)

Sakudo, Nakamura, Tsuji, Ikuta: "GPI-anchorless human prion protein is secreted and glycosylated but lacks superoxide dismutase activity." dans: International journal of molecular medicine, Vol. 21, Issue 2, pp. 217-22, (2008) (PubMed).

Détails sur PRNP

Antigène: PRNP (Prion Protein (PRNP))

Autre désignation: Prion Protein (PRNP Produits)

Synonymes: anticorps ASCR, anticorps AltPrP, anticorps CD230, anticorps CJD, anticorps GSS, anticorps KURU, anticorps PRIP, anticorps PrP, anticorps PrP27-30, anticorps PrP33-35C, anticorps PrPc, anticorps p27-30, anticorps Prn, anticorps Prn-p, anticorps prp, anticorps cjd, anticorps prion, anticorps prp(c), anticorps MGC84114, anticorps PRP, anticorps PRPC, anticorps Prp, anticorps SIP, anticorps PRNP, anticorps AA960666, anticorps AI325101, anticorps PrP, anticorps PrPC, anticorps PrPSc, anticorps Prn-i, anticorps Sinc, anticorps prP27-30, anticorps prP33-35C, anticorps PrP-1, anticorps PrP1, anticorps prnprs1, anticorps stPrP-1, anticorps zgc:123004, anticorps prion protein, anticorps prion protein S homeolog, anticorps prion protein b, anticorps PRNP, anticorps Prnp, anticorps prnp.S, anticorps prnpb

Sujet: Prion protein PrP is a membrane glycosylphosphatidylinositol(GPI) anchored glycoprotein highly expressed in neuron and glia cells as well as immune and reproductive cells. Mutations in the octapeptide repeat regions as well as elsewhere in this gene have been associated with neurodegenerative diseases such as Creutzfeldt Jakob disease, fatal familial insomnia, Gerstmann Straussler disease, Huntington disease like 1, and kuru. The infectious isoform of PrPC, known as PrPSc, is able to convert normal PrPPC proteins into the infectious isoform, which is insoluble amyloid aggregate, by changing their. Mature PrP protein in human consists of 209 amino acids. Several forms exist, one cell surface form anchored via and two forms, which are responsible for appearance of multiple bands in SDS-PAGE.

UniProt: P04156

Pathways: Transition Metal Ion Homeostasis, Activated T Cell Proliferation