DUSP12 anticorps

N° du produit ABIN2457984

Détail du produit anti-DUSP12 anticorps

Antigène: DUSP12 (Dual Specificity Phosphatase 12 (DUSP12))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DUSP12 est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogène: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human DUSP12.

Information d'application

Indications d'application: DUSP12 antibody can be used for detection of DUSP12 by ELISA at 1:1562500. DUSP12 antibody can be used for detection of DUSP12 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Conseil sur la manipulation: As with any antibody avoid repeat freeze-thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: For short periods of storage (days) store at 4 °C. For longer periods of storage, store DUSP12 antibody at -20 °C.

Détails sur DUSP12

Antigène: DUSP12 (Dual Specificity Phosphatase 12 (DUSP12))

Autre désignation: DUSP12 (DUSP12 Produits)

Synonymes: anticorps DUSP12, anticorps dusp12, anticorps zgc:114069, anticorps MGC154526, anticorps DUSP1, anticorps YVH1, anticorps 1190004O14Rik, anticorps AA027408, anticorps AW049275, anticorps ESTM36, anticorps LMW-DSP4, anticorps T-DSP4, anticorps VH1, anticorps mVH1, anticorps GKAP, anticorps dual specificity phosphatase 12, anticorps dual specificity phosphatase 12 L homeolog, anticorps Dual specificity protein phosphatase 12, anticorps dual specificity protein phosphatase 12, anticorps DUSP12, anticorps dusp12, anticorps dusp12.L, anticorps GL50803_36315, anticorps MGYG_01770, anticorps Dusp12

Sujet: DUSP12 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP12 is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain.The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain.

Poids moléculaire: 38 kDa

ID gène: 11266

NCBI Accession: NP_009171

UniProt: Q9UNI6

Pathways: Regulation of Carbohydrate Metabolic Process