REC8 anticorps

N° du produit ABIN2459159

Détail du produit anti-REC8 anticorps

Antigène: REC8 (REC8 Homolog (Yeast) (REC8))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp REC8 est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogène: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human REC8.

Information d'application

Indications d'application: REC8 antibody can be used for detection of REC8 by ELISA at 1:1562500. REC8 antibody can be used for detection of REC8 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Conseil sur la manipulation: As with any antibody avoid repeat freeze-thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: For short periods of storage (days) store at 4 °C. For longer periods of storage, store REC8 antibody at -20 °C.

Détails sur REC8

Antigène: REC8 (REC8 Homolog (Yeast) (REC8))

Autre désignation: REC8 (REC8 Produits)

Synonymes: anticorps Rec8L1, anticorps mrec, anticorps HR21spB, anticorps REC8L1, anticorps Rec8p, anticorps REC8 meiotic recombination protein, anticorps REC8 homolog (yeast), anticorps REC8, anticorps Rec8

Sujet: REC8 is required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II.This gene encodes a member of the kleisin family of SMC (structural maintenance of chromosome) protein partners. The protein localizes to the axial elements of chromosomes during meiosis in both oocytes and spermatocytes. In the mouse, the homologous protein is a key component of the meiotic cohesion complex, which regulates sister chromatid cohesion and recombination between homologous chromosomes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene.

Poids moléculaire: 62 kDa

ID gène: 9985

NCBI Accession: NP_005123

UniProt: O95072