p107 anticorps
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- Antigène Voir toutes p107 (RBL1) Anticorps
- p107 (RBL1) (Retinoblastoma-Like 1 (p107) (RBL1))
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Reactivité
- Humain, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp p107 est non-conjugé
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Application
- Western Blotting (WB), ELISA
- Purification
- Antibody is purified by peptide affinity chromatography method.
- Immunogène
- Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human RBL1.
- Top Product
- Discover our top product RBL1 Anticorps primaire
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- Indications d'application
- RBL1 antibody can be used for detection of RBL1 by ELISA at 1:62500. RBL1 antibody can be used for detection of RBL1 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.
- Concentration
- 1 mg/mL
- Buffer
- Antibody is lyophilized in PBS buffer with 2 % sucrose.
- Conseil sur la manipulation
- As with any antibody avoid repeat freeze-thaw cycles.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- For short periods of storage (days) store at 4 °C. For longer periods of storage, store RBL1 antibody at -20 °C.
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- Antigène
- p107 (RBL1) (Retinoblastoma-Like 1 (p107) (RBL1))
- Autre désignation
- RBL1 (RBL1 Produits)
- Synonymes
- anticorps p107, anticorps prb1, anticorps fj58e06, anticorps wu:fj58e06, anticorps CP107, anticorps PRB1, anticorps AW547426, anticorps retinoblastoma-like 1 L homeolog, anticorps RB transcriptional corepressor like 1, anticorps retinoblastoma-like 1 (p107), anticorps retinoblastoma-like 1, anticorps rbl1.L, anticorps RBL1, anticorps rbl1, anticorps Rbl1
- Sujet
- RBL1 is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene.
- Poids moléculaire
- 115 kDa
- ID gène
- 5933
- NCBI Accession
- NP_899662
- Pathways
- Cycle Cellulaire, Mitotic G1-G1/S Phases
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