ELK1 anticorps (truncated)
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- Antigène Voir toutes ELK1 Anticorps
- ELK1 (ELK1, Member of ETS Oncogene Family (ELK1))
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Épitope
- truncated
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp ELK1 est non-conjugé
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Application
- Western Blotting (WB), ELISA
- Immunogène
- Ni-NTA purified truncated recombinant ELK1 expressed in E. Coli strain BL21 (DE3).
- Clone
- 7E10D5-7E10E8
- Isotype
- IgG1
- Top Product
- Discover our top product ELK1 Anticorps primaire
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- Indications d'application
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Western Blot:1:500 - 1:1,000
ELISA:Propose dilution 1:10,000.
Determining optimal working dilutions by titration test. - Restrictions
- For Research Use only
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- Buffer
- Ascitic fluid containing 0.03 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Stock
- -20 °C
- Stockage commentaire
- ELK1 monoclonal antibody can be stored at -20 °C, stable for one year.
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- Antigène
- ELK1 (ELK1, Member of ETS Oncogene Family (ELK1))
- Autre désignation
- ELK1 (ELK1 Produits)
- Synonymes
- anticorps Elk-1, anticorps Xelk, anticorps Xelk-1, anticorps elk-1, anticorps elk1, anticorps ELK1, ETS transcription factor, anticorps ELK1, member of ETS oncogene family, anticorps ETS domain-containing protein Elk-1, anticorps ELK1, member of ETS oncogene family S homeolog, anticorps ELK1, anticorps Elk1, anticorps Tsp_02690, anticorps elk1, anticorps elk1.S
- Sujet
- The transcription factor ELK1 is a family of member of ETS oncogene family and of the ternary complex factor (TCF) subfamily,which is located on chromosome Xp11.2 and stimulates transcription. binds to purine-rich DNA sequences. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. Elk1 is phosphorylated by MAP kinase pathways at a cluster of S/T motifs at its C terminus,It appears to be a direct target of activated MAP kinase. Biochemical studies indicate that Elk1 is a good substrate for MAP kinase, the kinetics of Elk1phosphorylation and activation correlate with MAP kinase activity, and interfering mutants of MAP kinase block Elk1 activation in vivo. More recent studies have shown that Elk1 is also a target of the Stress Activated Kinase SAPK/JNK. Phosphorylation of Elk1 has also been implicated in synaptic plasticity in the adult hippocampus.
- ID gène
- 2002
- UniProt
- P19419
- Pathways
- Signalisation MAPK, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling
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