LEFTY2 anticorps

N° du produit ABIN2470659

Détail du produit anti-LEFTY2 anticorps

Antigène: LEFTY2 (Left-Right Determination Factor 2 (LEFTY2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp LEFTY2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Specificité: A BALB/c mouse was immunized with a recombinant form of 6X HIS tagged human LEFTY.

Purification: Protein A Column

Immunogène: LEFTY2 monoclonal antibody was raised against recombinant LEFTY2 (Human). Hybridoma: Produced by the fusion between BALB/c mouse splenocytes and mouse Sp2/0 myeloma cells using conventional hybridoma technology.

Clone: 7C5G1H6H10

Isotype: IgG2a kappa

Information d'application

Indications d'application: LEFTY2 antibody can be used in immunohistochemistry starting at 2.5 μg/mL.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: As with all antibodies avoid freeze/thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: Store LEFTY2 antibody at 4 °C or -20 °C.

Détails sur LEFTY2

Antigène: LEFTY2 (Left-Right Determination Factor 2 (LEFTY2))

Autre désignation: LEFTY2 (LEFTY2 Produits)

Synonymes: anticorps EBAF, anticorps LEFTA, anticorps LEFTYA, anticorps TGFB4, anticorps AI450052, anticorps Ebaf, anticorps Leftb, anticorps Stra3, anticorps Tgfb4, anticorps lefty, anticorps lefty-1, anticorps atv2, anticorps cb720, anticorps fe38b03, anticorps wu:fe38b03, anticorps 6030463A22Rik, anticorps AV214969, anticorps Lefta, anticorps Ebaf2, anticorps left-right determination factor 2, anticorps left right determination factor 1, anticorps lefty2, anticorps Left-right determination factor 2, anticorps left-right determination factor 2-like, anticorps LEFTY2, anticorps Lefty1, anticorps lft2, anticorps Lefty2, anticorps LOC699676, anticorps LOC100232580

Sujet: During vertebrate embryogenesis, a left-right axis is established. Secreted growth factors of the TGF-beta family, including gene products derived from nodal, lefty-1 and lefty-2, play crucial roles in establishing left-right asymmetries. TGF-beta (Transforming growth factor-beta) is a pleiotropic cytokine that regulates growth and differentiation of diverse types of cells. TGF-beta actions are directed by ligand-induced activation of TGF-beta receptors. Complexes formed move into the nucleus, where they act as components of a transcriptional complex. Lefty, a novel member of the TGF-beta superfamily, inhibits TGF-beta signaling. Lefty acts to inhibit phosphorylation of Smad2 following activation of the TGF-beta receptor. Lefty also inhibits events downstream from R-Smad phosphorylation. Lefty provides a repressed state of TGF-beta-responsive genes. The Lefty family is comprised of Lefty 1 and Lefty 2 in mouse, and Lefty A and Lefty B in humans. Members of the TGF-beta superfamily require processing for their activation. Cleavage is therefore an essential step for Lefty activation. Lefty is synthesized as a large inactive precursor (42 kDa) that must be endoproteolytically processed to release the bioactive polypeptide (28 kDa and 34 kDa forms). The 28 kDa form induces MAPK activity.

ID gène: 7044

UniProt: O00292