SAG anticorps (pSer412)

N° du produit ABIN2567047

Détail du produit anti-SAG anticorps

Antigène: SAG (S-Antigen, Retina and Pineal Gland (Arrestin) (SAG))

Épitope: pSer412

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SAG est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificité: The antibody detects endogenous levels of Arrestin-1 only when phosphorylated at serine 412.

Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogène: Arrestin 1 (phospho Ser412) antibody was raised against a peptide sequence around phosphorylation site of Serine 412 (T-G-S (p)-P-Q) derived from Human Arrestin 1.

Isotype: IgG

Information d'application

Indications d'application: Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store antibody at -20°C for up to one year.

Détails sur SAG

Antigène: SAG (S-Antigen, Retina and Pineal Gland (Arrestin) (SAG))

Autre désignation: Arrestin 1 (SAG Produits)

Synonymes: anticorps RP47, anticorps S-AG, anticorps MGC75721, anticorps MGC84416, anticorps sag, anticorps zgc:114197, anticorps SAGMR, anticorps SANTI, anticorps ARR, anticorps sag1, anticorps A930001K18Rik, anticorps Arr1, anticorps Irbp, anticorps arrestin, anticorps S-antigen visual arrestin, anticorps S-antigen, anticorps S-antigen; retina and pineal gland (arrestin), anticorps S-antigen; retina and pineal gland (arrestin) S homeolog, anticorps S-antigen; retina and pineal gland (arrestin) b, anticorps S-antigen, retina and pineal gland (arrestin), anticorps S-antigen; retina and pineal gland (arrestin) L homeolog, anticorps SAG, anticorps PF10_0343, anticorps sag, anticorps sag.S, anticorps sagb, anticorps Sag, anticorps sag.L

Sujet: Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein, the binding appears to require additional receptor determinants exposed only in the active receptor conformation.

Poids moléculaire: 50 kDa

ID gène: 408

NCBI Accession: NP_004032

UniProt: P49407

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling