BLK anticorps (pTyr501)

N° du produit ABIN2567060

Détail du produit anti-BLK anticorps

Antigène: BLK (B Lymphoid Tyrosine Kinase (BLK))

Épitope: pTyr501

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BLK est non-conjugé

Application: Immunohistochemistry (IHC)

Specificité: The antibody detects endogenous levels of BLK only when phosphorylated at tyrosine 501.

Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogène: BLK (phospho Tyr501) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 501 (R-Q-Y (p)-E-L) derived from Human BLK.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store antibody at -20°C for up to one year.

Détails sur BLK

Antigène: BLK (B Lymphoid Tyrosine Kinase (BLK))

Autre désignation: BLK (BLK Produits)

Synonymes: anticorps bltk, anticorps si:dkey-33i22.2, anticorps zgc:136231, anticorps MODY11, anticorps BLK proto-oncogene, Src family tyrosine kinase, anticorps B lymphoid kinase, anticorps blk, anticorps BLK, anticorps Blk

Sujet: Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor.

Poids moléculaire: 57 kDa

ID gène: 640

NCBI Accession: NP_001706

UniProt: P51451

Pathways: Positive Regulation of Peptide Hormone Secretion, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling