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CTLA4 anticorps

CTLA4 Reactivité: Humain FACS Hôte: Souris Monoclonal BNI3 unconjugated
N° du produit ABIN2567240
  • Antigène Voir toutes CTLA4 Anticorps
    CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
    Reactivité
    • 93
    • 63
    • 34
    • 4
    • 3
    Humain
    Hôte
    • 58
    • 50
    • 18
    • 12
    • 1
    • 1
    Souris
    Clonalité
    • 84
    • 53
    • 2
    Monoclonal
    Conjugué
    • 63
    • 17
    • 13
    • 12
    • 8
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CTLA4 est non-conjugé
    Application
    • 84
    • 63
    • 51
    • 35
    • 19
    • 14
    • 13
    • 13
    • 10
    • 7
    • 7
    • 6
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Specificité
    The BNI3 monoclonal antibody specifically reacts with human CD152, the Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4).
    Purification
    The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/μg of the protein.
    Clone
    BNI3
    Isotype
    IgG2a kappa
    Top Product
    Discover our top product CTLA4 Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    2.0 mg/mL
    Buffer
    Phosphate-buffered aqueous solution, ph7.2.
    Stock
    4 °C
    Stockage commentaire
    The product should be stored undiluted at 4°C. Do not freeze.
  • Antigène
    CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
    Autre désignation
    CD152 (CTLA4 Produits)
    Synonymes
    anticorps CTLA-4, anticorps CTLA4, anticorps CD152, anticorps Cd152, anticorps Ctla-4, anticorps Ly-56, anticorps CD, anticorps CELIAC3, anticorps GRD4, anticorps GSE, anticorps IDDM12, anticorps sCTLA4, anticorps cytotoxic T-lymphocyte associated protein 4, anticorps cytotoxic T-lymphocyte-associated protein 4, anticorps CTLA4, anticorps Ctla4
    Sujet
    The BNI3 monoclonal antibody specifically reacts with human CD152, the Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4). CTLA-4 is expressed on activated CD28+ T cells, and binds the B7 family members B7-1 (CD80) and B7-2 (CD86). The structure of CTLA-4 is similar to the structure of CD28, but the two molecules seem to have opposite roles on the T lymphocytes. CTLA-4 inhibits the progression of T cell activation, while CD28 stimulates it. This result explains the stimulating role that the immobilization of BNI3 plays on the T lymphocytes proliferation induced by CD28.
    ID gène
    1493
    UniProt
    P16410
    Pathways
    Cancer Immune Checkpoints
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