GAB2 anticorps (pTyr643)

N° du produit ABIN2568160

Détail du produit anti-GAB2 anticorps

Antigène: GAB2 (GRB2-Associated Binding Protein 2 (GAB2))

Épitope: pTyr643

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GAB2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificité: The antibody detects endogenous levels of Gab2 only when phosphorylated at tyrosine 643.

Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogène: Gab2 (phospho Tyr643) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 643 (V-D-Y (p)-V-Q) derived from Human Gab2 .

Isotype: IgG

Information d'application

Indications d'application: Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store antibody at -20°C for up to one year.

Détails sur GAB2

Antigène: GAB2 (GRB2-Associated Binding Protein 2 (GAB2))

Autre désignation: Gab2 (GAB2 Produits)

Synonymes: anticorps GAB2, anticorps AI463667, anticorps D130058I17Rik, anticorps p97, anticorps GRB2 associated binding protein 2, anticorps GRB2-associated binding protein 2, anticorps growth factor receptor bound protein 2-associated protein 2, anticorps GAB2, anticorps gab2, anticorps Gab2

Sujet: This gene is a member of the GRB2-associated binding protein (GAB) gene family and is similar to the GAB1 gene. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.

Poids moléculaire: 74 kDa

ID gène: 9846

NCBI Accession: NP_536739

UniProt: Q9UQC2

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, BCR Signaling, L'effet Warburg