MSK1 anticorps (pSer212)

N° du produit ABIN2568371

Détail du produit anti-MSK1 anticorps

Antigène: MSK1 (RPS6KA5) (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 5 (RPS6KA5))

Épitope: pSer212

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MSK1 est non-conjugé

Application: Western Blotting (WB)

Specificité: The antibody detects endogenous level of MSK1 only when phosphorylated at serine 212.

Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogène: MSK1 (phospho Ser212) antibody was raised against a peptide sequence around phosphorylation site of serine 212 (A-Y-S (p)-F-C) derived from Human MSK1.

Isotype: IgG

Information d'application

Indications d'application: Western Blot: 1:500~1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store antibody at -20°C for up to one year.

Détails sur MSK1

Antigène: MSK1 (RPS6KA5) (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 5 (RPS6KA5))

Autre désignation: MSK1 (RPS6KA5 Produits)

Synonymes: anticorps MSK1, anticorps MSPK1, anticorps RLPK, anticorps 3110005L17Rik, anticorps 6330404E13Rik, anticorps AI854034, anticorps Msk1, anticorps ribosomal protein S6 kinase A5, anticorps ribosomal protein S6 kinase, polypeptide 5, anticorps RPS6KA5, anticorps Rps6ka5

Sujet: Serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). Essential role in the control of RELA transcriptional activity in response to TNF. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14).

Poids moléculaire: 90 kDa

ID gène: 9252

NCBI Accession: NP_004746

UniProt: O75582

Pathways: Signalisation MAPK, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades