TLR3 anticorps (N-Term)

N° du produit ABIN265140

Détail du produit anti-TLR3 anticorps

Antigène: TLR3 (Toll-Like Receptor 3 (TLR3))

Épitope: N-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TLR3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Purification: Purified

Immunogène: Peptide corresponding to 15 amino acids near the amino terminus of human TLR3

Isotype: IgG

Information d'application

Indications d'application: Western Blot: 1 to 2 μg/mL: K562 cell lysate can be used as a positive control. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: Phosphate buffered saline with 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.

Détails sur TLR3

Antigène: TLR3 (Toll-Like Receptor 3 (TLR3))

Autre désignation: CD283 / TLR3 (TLR3 Produits)

Synonymes: anticorps CD283, anticorps IIAE2, anticorps AI957183, anticorps zgc:123006, anticorps toll like receptor 3, anticorps toll-like receptor 3, anticorps TLR3, anticorps Tlr3, anticorps tlr3

Sujet: Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1,2). The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors (3) so the organism can respond to potential infection. TLR3 is known to recognize viral double-stranded (ds) RNA, a molecular pattern associated with viral infection (4). Recently it has been shown to recognize viruses such as Influenza A (5) and West Nile Virus and can mediate entry of at least West Nile Virus (6). TLR3 is ocated in the membrane and expressed at high level in placenta and pancreas. Also detected in CD11c+ immature dendritic cells. Only expressed in dendritic cells and not in other leukocytes, including monocyte precursors.(7)Synonyms: Toll-like receptor 3

ID gène: 9606

UniProt: O15455

Pathways: Signalisation TLR, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades