GFRA1 anticorps

N° du produit ABIN265434

Détail du produit anti-GFRA1 anticorps

Antigène: GFRA1 (GDNF Family Receptor alpha 1 (GFRA1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GFRA1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody detects endogenous levels of GFR alpha-1 protein. (region surrounding Lys90)

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity Chromatography using epitope-specific immunogen

Information d'application

Indications d'application: ELISA: 1: 1000approx. 1: 20000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur GFRA1

Antigène: GFRA1 (GDNF Family Receptor alpha 1 (GFRA1))

Autre désignation: GFRA1 / GDNFR-alpha (GFRA1 Produits)

Synonymes: anticorps gdnfr, anticorps ret1l, anticorps retl1, anticorps trnr1, anticorps gdnfra, anticorps MGC122616, anticorps gfr-alpha-1, anticorps GDNFR, anticorps GDNFRA, anticorps GFR-ALPHA-1, anticorps RET1L, anticorps RETL1, anticorps TRNR1, anticorps GDNFRALPHA, anticorps GFRA1, anticorps AU042498, anticorps gfralpha1a, anticorps zgc:110129, anticorps GDNF family receptor alpha 1, anticorps glial cell line derived neurotrophic factor family receptor alpha 1, anticorps gdnf family receptor alpha 1a, anticorps gfra1, anticorps GFRA1, anticorps Gfra1, anticorps gfra1a

Sujet: Glial cell line-derived neurotrophic factor (GDNF) and the related neurotrophic factor neurturin (NTN) are potent survival factors for central and peripheral neurons. GDNF is a glycosylated, disulfide-bonded homodimer that is distantly related to the TGFβ superfamily of growth factors. Three receptors for these factors, GFRα-1 (also designated GDNFR-α, RETL1 or TrnR-1), GFRα-2 (also designated GDNFR-β, RETL2, NTNR-α or TrnR-2) and GFRα-3 have been identified. The receptors do not contain transmembrane domains and are attached to the cell membrane by glycosyl-phosphoinositol linkage. Both GFRα-1 and GFRα-2 have been shown to mediate the GDNF-dependent and NTN-dependent phosphorylation and activation of the tyrosine kinase Ret. GFRα-3 is expressed only during development.Synonyms: GDNF family receptor alpha-1, GDNF receptor alpha, GDNFRA, GFR-alpha-1, RET ligand 1, RETL1, TGF-beta-related neurotrophic factor receptor 1, TRNR1

Poids moléculaire: approx. 51 kDa

ID gène: 2674

NCBI Accession: NP_005255

UniProt: P56159