SIRPA anticorps (PE/Dazzle™ 594)

N° du produit ABIN2659659

Détail du produit anti-SIRPA anticorps (PE/Dazzle™ 594)

Antigène: SIRPA (Signal-Regulatory Protein alpha (SIRPA))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp SIRPA est conjugé à/à la PE/Dazzle™ 594

Application: Flow Cytometry (FACS)

Purification: The antibody was purified by affinity chromatography and conjugated with PE/Dazzle™ 594 under optimal conditions. The solution is free of unconjugated PE/Dazzle™ 594 and unconjugated antibody.

Clone: P84

Isotype: IgG1 kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.2 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Protect from prolonged exposure to light. Do not freeze.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C.

Détails sur SIRPA

Antigène: SIRPA (Signal-Regulatory Protein alpha (SIRPA))

Autre désignation: CD172a (SIRPA Produits)

Synonymes: anticorps BIT, anticorps CD172A, anticorps MFR, anticorps MYD-1, anticorps P84, anticorps PTPNS1, anticorps SHPS1, anticorps SIRP, anticorps SIRPA, anticorps SIRP-A1, anticorps SIRP-B1, anticorps AI835480, anticorps Bit, anticorps CD172a, anticorps Ptpns1, anticorps SHP-1, anticorps SHPS-1, anticorps swc3, anticorps signal regulatory protein alpha, anticorps myeloperoxidase, anticorps signal-regulatory protein alpha, anticorps tyrosine-protein phosphatase non-receptor type substrate 1, anticorps SIRPA, anticorps MPO, anticorps LOC458039, anticorps LOC100400378, anticorps LOC100590224, anticorps Sirpa

Sujet: CD172a, also known as SIRPα, is a type I transmembrane protein with one V-set Ig-like and two C-set Ig-like domains in the extracellular portion, and two ITIM motifs and a proline-rich region in the cytoplasmic tail. CD172a is expressed by monocytes, macrophages, myeloid cells, and neuronal tissue. The phosphorylation of SIRPα ITIMs induces the recruitment and activation of the tyrosine phosphatases PTPN6 and PTPN11, resulting in the negative regulation of several biological processes. The ligands of CD172a are CD47, SP-A, and SP-D.