BIN1 anticorps

N° du produit ABIN2664071

Détail du produit anti-BIN1 anticorps

Antigène: BIN1 (Bridging Integrator 1 (BIN1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp BIN1 est non-conjugé

Application: Flow Cytometry (FACS)

Purification: The antibody was purified by affinity chromatography.

Clone: 99D

Isotype: IgG2b

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C.

Détails sur BIN1

Antigène: BIN1 (Bridging Integrator 1 (BIN1))

Autre désignation: Bin1 (BIN1 Produits)

Synonymes: anticorps bin1, anticorps MGC53185, anticorps amph2, anticorps amphl, anticorps sh3p9, anticorps MGC76187, anticorps cb57, anticorps zgc:86701, anticorps BIN1, anticorps AMPH2, anticorps AMPHL, anticorps SH3P9, anticorps ALP-1, anticorps Amphl, anticorps BRAMP-2, anticorps bridging integrator 1, anticorps bridging integrator 1 S homeolog, anticorps bridging integrator 1b, anticorps BIN1, anticorps bin1.S, anticorps bin1, anticorps bin1b, anticorps Bin1

Sujet: Bridging integrator 1 (Bin1) is a conserved member of the BAR family of genes that have been implicated in diverse cellular processes including endocytosis, cell polarity, programmed cell death, and stress signaling. It is involved in membrane remodeling and is one of the important genes in predicting risk for Alzheimer's disease (AD). Alternative splicing of the gene results in ten transcript variants. Isoforms 1-7 are expressed predominantly in the central nervous system. Isoform 8 is expressed specifically in muscle, and defects in BIN1 cause autosomal recessive myotubular myopathy. Isoforms 9 and 10 are ubiquitously expressed and may act as tumor repressors.