IL7R anticorps

N° du produit ABIN2688947

Détail du produit anti-IL7R anticorps

Antigène: IL7R (Interleukin 7 Receptor (IL7R))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IL7R est non-conjugé

Application: Flow Cytometry (FACS)

Marque: BD Pharmingen™

Attributs du produit: Monoclonal antibody hIL-7R-M21 reacts with the 60 - 90 kDa glycoprotein, CD127. CD127 is also known as the IL-7 receptor alpha (IL-7Rα). The receptor is a heterodimer composed of the CD127 and the common gamma chain, shared by other cytokine receptors (IL-2R, IL-4R, IL-9R, and IL-15R). CD127 is expressed on thymocytes, T- and B-cell progenitors, mature T cells, and some lymphoid and myeloid cells. In vitro experiments show the expression of CD127 is down-regulated following T cell activation. Studies indicate that the IL-7 Receptor plays an important role in the proliferation and differentiation of mature T cells. Recently, it has been shown that low surface expression of CD127, in combination with intermediate to high suface expression of CD25, the α chain of the IL-2 receptor, can distinguish between human regulatory and conventional CD4+ T cells in human adult and cord blood, lymph nodes and thymus. Profile of CD127 expression on peripheral blood lymphocytes analyzed by flow cytometry. Second step staining with Cat. No. 555988.

BD Pharmingen™ Purified Mouse Anti-Human CD127 - Purified - Clone HIL-7R-M21 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Clone: HIL-7R

Isotype: IgG1 kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C.

Références pour anticorps anti-IL7R (ABIN2688947)

Akashi, Traver, Kondo, Weissman: "Lymphoid development from hematopoietic stem cells." dans: International journal of hematology, Vol. 69, Issue 4, pp. 217-26, (1999) (PubMed).

Appasamy: "Biological and clinical implications of interleukin-7 and lymphopoiesis." dans: Cytokines, cellular & molecular therapy, Vol. 5, Issue 1, pp. 25-39, (1999) (PubMed).

Hofmeister, Khaled, Benbernou, Rajnavolgyi, Muegge, Durum: "Interleukin-7: physiological roles and mechanisms of action." dans: Cytokine & growth factor reviews, Vol. 10, Issue 1, pp. 41-60, (1999) (PubMed).

Goodwin, Friend, Ziegler, Jerzy, Falk, Gimpel, Cosman, Dower, March, Namen: "Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily." dans: Cell, Vol. 60, Issue 6, pp. 941-51, (1990) (PubMed).

Détails sur IL7R

Antigène: IL7R (Interleukin 7 Receptor (IL7R))

Autre désignation: CD127 (IL7R Produits)

Synonymes: anticorps IL7R, anticorps CD127, anticorps IL-7Ralpha, anticorps CDW127, anticorps IL-7R-alpha, anticorps IL7RA, anticorps ILRA, anticorps IL-7RA, anticorps interleukin 7 receptor, anticorps IL7R, anticorps Il7r

Sujet: Synonyms: Interleukin-7 receptor alpha

Pathways: Signalistation JAK/STAT, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Regulation of Cell Size