Prostaglandin D2 Receptor 2 (PTGDR2) anticorps

N° du produit ABIN2689160

Détail du produit

Antigène: Prostaglandin D2 Receptor 2 (PTGDR2)

Reactivité: Humain

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Inconjugué

Application: Flow Cytometry (FACS)

Marque: BD Pharmingen™

Attributs du produit: Monoclonal antibody BM16 reacts with CRTH2 (chemoattractant receptor-homologous molecule expressed on Th2 cells). CRTH2 is a member of the G protein-coupled leukocyte chemoattractant receptor family and it is expressed on Th2, but not Th1 lineage cells. It is detectable on CD4+ T cells in fresh PBMC and no significant expression on B cells and NK cells. CRTH2 is also expressed on peripheral blood basophils and eosinophils, suggesting its involvement allergic reactions. Phenotypic analysis of CD4+ T cells expressing CRTH2 demonstrated CD45RA-, CD45RO+ and CD25+. These cells produce Th2- but little or no Th1-type cytokines upon stimulation with PMA and Ionomycin. Profile of anti-CRTH2 (BM16) reactivity on HUT 78 cells analyzed by flow cytometry. Second step staining with Cat. No. 554016.

BD Pharmingen™ Purified Rat Anti-Human CD294 - Purified - Clone BM16 - Isotype Rat IgG2a, κ - Reactivity Hu - 0.1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Transfectant cells

Clone: BM16

Isotype: IgG2a kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C.

Référence

Cosmi, Annunziato, Galli MIG, Maggi RME, Nagata, Romagnani: "CRTH2 is the most reliable marker for the detection of circulating human type 2 Th and type 2 T cytotoxic cells in health and disease." dans: European journal of immunology, Vol. 30, Issue 10, pp. 2972-9, (2000) (PubMed).

Nagata, Hirai, Tanaka, Ogawa, Aso, Sugamura, Nakamura, Takano: "CRTH2, an orphan receptor of T-helper-2-cells, is expressed on basophils and eosinophils and responds to mast cell-derived factor(s)." dans: FEBS letters, Vol. 459, Issue 2, pp. 195-9, (1999) (PubMed).

Nagata, Tanaka, Ogawa, Kemmotsu, Imai, Yoshie, Abe, Tada, Nakamura, Sugamura, Takano: "Selective expression of a novel surface molecule by human Th2 cells in vivo." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 3, pp. 1278-86, (1999) (PubMed).

Détail du antigène

Antigène: Prostaglandin D2 Receptor 2 (PTGDR2)

Autre désignation: CD294 (PTGDR2 Produits)

Synonymes: anticorps CD294, anticorps CRTH2, anticorps DL1R, anticorps DP2, anticorps GPR44, anticorps Crth2, anticorps Grp45, anticorps Ptgdr2, anticorps Gpr44, anticorps prostaglandin D2 receptor 2, anticorps PTGDR2, anticorps Ptgdr2

Sujet: Synonyms: CRTH2

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling