Patched 1 anticorps

N° du produit ABIN271777

Détail du produit anti-Patched 1 anticorps

Antigène: Patched 1 (PTCH1)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Patched 1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody detects endogenous levels of Patched protein. (region surrounding Ala2)

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity Chromatography using epitope-specific immunogen

Information d'application

Indications d'application: ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur Patched 1

Antigène: Patched 1 (PTCH1)

Autre désignation: PTCH1 (PTCH1 Produits)

Synonymes: anticorps BCNS, anticorps HPE7, anticorps NBCCS, anticorps PTC, anticorps PTC1, anticorps PTCH, anticorps PTCH11, anticorps lep, anticorps ptc1, anticorps ptc2, anticorps Ptch, anticorps Ptch2, anticorps Ptc-1, anticorps XPtc1, anticorps patched, anticorps patched1, anticorps A230106A15Rik, anticorps Ptc, anticorps Ptc1, anticorps mes, anticorps patched 1, anticorps patched 1 L homeolog, anticorps Protein patched homolog 1, anticorps PTCH1, anticorps ptch1, anticorps Ptch1, anticorps ptch1.L, anticorps ptc-1

Sujet: PTCH (Patched protein homolog 1) is a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). PTCH associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal.PTCH has a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis. PTCH is expressed in the adult brain, lung, liver, heart, placenta, skeletal muscle, pancreas and kidney. It is also expressed in tumor cells but not in normal skin. During development PTCH is found in all major target tissues of sonic hedgehog, such as the ventral neural tube, somites, and tissues surrounding the zone of polarizing activity of the limb bud. Defects in PTCH are probably the cause of basal cell nevus syndrome also known as Gorlin syndrome or Gorlin-Goltz syndromeSynonyms: PTC, PTC1, PTCH, Patched 1, Protein patched homolog 1

Poids moléculaire: approx. 160 kDa

ID gène: 5727

NCBI Accession: NP_000255

UniProt: Q13635

Pathways: Signalisation Hedgehog, Carbohydrate Homeostasis, Tube Formation