GIT2 anticorps

N° du produit ABIN272229

Détail du produit anti-GIT2 anticorps

Antigène: GIT2 (G Protein-Coupled Receptor Kinase Interactor 2 (GIT2))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GIT2 est non-conjugé

Application: Western Blotting (WB)

Specificité: This antibody detects endogenous levels of GIT2 protein. (region surrounding Asp391)

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity Chromatography using epitope-specific immunogen.

Information d'application

Indications d'application: ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur GIT2

Antigène: GIT2 (G Protein-Coupled Receptor Kinase Interactor 2 (GIT2))

Autre désignation: GIT2 (GIT2 Produits)

Synonymes: anticorps CAT-2, anticorps CAT2, anticorps cat-2, anticorps xgit2, anticorps git2, anticorps si:dkey-234h16.4, anticorps 1500036H07Rik, anticorps 5830420E16Rik, anticorps 6430510B20Rik, anticorps 9630056M03Rik, anticorps B230104M05Rik, anticorps mKIAA0148, anticorps zgc:158416, anticorps GIT ArfGAP 2, anticorps G protein-coupled receptor kinase interacting ArfGAP 2, anticorps G protein-coupled receptor kinase interacting ArfGAP 2a, anticorps G protein-coupled receptor kinase-interactor 2, anticorps G protein-coupled receptor kinase interacting ArfGAP 2 L homeolog, anticorps G protein-coupled receptor kinase interacting ArfGAP 2b, anticorps GIT2, anticorps git2, anticorps git2a, anticorps Git2, anticorps git2.L, anticorps git2b

Sujet: Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. G protein-coupled receptor kinases(GRKs) are activated by activated G protein-coupled receptors, and they function to phosphorylate and inactivate cell surface receptors in the heterotrimeric G protein signaling cascade. GIT1 (for GRK-interactor 1) and GIT2 are GTPase-activating proteins (GAP) for members of the ADP ribosylation factor (ARF) family of small GTP-binding proteins, which are involved in vesicular trafficking. GIT1 overexpression results in reduced internalization and resensitization of β2-adrenergic receptor, thus reducing β2-adrenergic receptor signaling.Synonyms: ARF GTPase-activating protein GIT2, CAT2, Cool-interacting tyrosine-phosphorylated protein 2, G protein-coupled receptor kinase-interactor 2, GRK-interacting protein 2, KIAA0148

Poids moléculaire: approx. 84 kDa

ID gène: 9815

NCBI Accession: NP_001128685

UniProt: Q14161

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling