CAND1 anticorps (Middle Region)

N° du produit ABIN2775887

Détail du produit anti-CAND1 anticorps

Antigène: CAND1 (Cullin-Associated and Neddylation-Dissociated 1 (CAND1))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Cobaye, Chien, Cheval, Lapin, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CAND1 est non-conjugé

Application: Western Blotting (WB)

Séquence: AALLTIPEAE KSPLMSEFQS QISSNPELAA IFESIQKDSS STNLESMDTS

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Attributs du produit: This is a rabbit polyclonal antibody against CAND1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human CAND1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 1230 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur CAND1

Antigène: CAND1 (Cullin-Associated and Neddylation-Dissociated 1 (CAND1))

Autre désignation: CAND1 (CAND1 Produits)

Synonymes: anticorps TIP120, anticorps TIP120A, anticorps ATCAND1, anticorps CULLIN-ASSOCIATED AND NEDDYLATION DISSOCIATED 1, anticorps ETA2, anticorps HEMIVENATA, anticorps HVE, anticorps T8K22.14, anticorps T8K22_14, anticorps cullin-associated and neddylation dissociated, anticorps Tip120, anticorps Tip120A, anticorps fb78a05, anticorps wu:fb78a05, anticorps zgc:55729, anticorps tip120, anticorps tip120a, anticorps cand2, anticorps 2310038O07Rik, anticorps 6330512O03Rik, anticorps AI195005, anticorps AI846556, anticorps D10Ertd516e, anticorps Tp120a, anticorps mKIAA0829, anticorps cullin associated and neddylation dissociated 1, anticorps cullin-associated and neddylation dissociated, anticorps cullin-associated and neddylation-dissociated 1, anticorps cullin-associated and neddylation-dissociated 1 L homeolog, anticorps cullin-associated NEDD8-dissociated protein 1, anticorps cullin associated and neddylation disassociated 1, anticorps CAND1, anticorps Cand1, anticorps cand1, anticorps cand1.L, anticorps LOC100159824, anticorps LOC100177977

Sujet: CAND1 enhances transcription from various types of promoters. It is a regulatory protein that interferes with the assembly of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex and thereby down-regulates ubiquitination of target proteins. CAND1 prevents neddylation of CUL1 by physically blocking access to the neddylation site. CAND1 disrupts interactions between CUL1 and SKP1A and between CUL1 and F-box proteins.
Alias Symbols: DKFZp434M1414, FLJ10114, FLJ10929, FLJ38691, FLJ90441, KIAA0829, TIP120, TIP120A
Protein Interaction Partner: ISG15, SUMO2, SUMO3, UBE2D1, UBC, UBE2M, CUL1, ASB2, ASB1, PPM1G, PAWR, OSBP, KARS, GARS, CARS, APEH, STAT1, SHMT2, IPO7, SEC23A, JMJD6, HSPA4, TRMT112, ZYX, DCUN1D5, DCUN1D1, SRPK2, UBD, FBXL3, FN1, CFTR, vif, CA9, ECT2, NOTCH1, CUL4A, CUL5, RBX1, ERCC6,
Protein Size: 1230

Poids moléculaire: 136 kDa

ID gène: 55832

NCBI Accession: NM_018448, NP_060918

UniProt: Q86VP6

Pathways: Regulation of Actin Filament Polymerization