DROSHA anticorps (Middle Region)
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- Antigène Voir toutes DROSHA Anticorps
- DROSHA (Drosha, Ribonuclease Type III (DROSHA))
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Épitope
- Middle Region
- Reactivité
- Humain, Souris, Rat, Lapin, Chien, Cobaye, Boeuf (Vache), Cheval
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp DROSHA est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- AAMDALEKYN FPQMAHQKRF IERKYRQELK EMRWEREHQE REPDETEDIK
- Homologie
- Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 93%
- Attributs du produit
- This is a rabbit polyclonal antibody against RNASEN. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the middle region of human RNASEN
- Top Product
- Discover our top product DROSHA Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 1374 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- DROSHA (Drosha, Ribonuclease Type III (DROSHA))
- Autre désignation
- RNASEN (DROSHA Produits)
- Synonymes
- anticorps im:7150667, anticorps zgc:158612, anticorps ETOHI2, anticorps HSA242976, anticorps RANSE3L, anticorps RN3, anticorps RNASE3L, anticorps RNASEN, anticorps 1110013A17Rik, anticorps AI874853, anticorps Etohi2, anticorps Rn3, anticorps Rnasen, anticorps RGD1307626, anticorps ribonuclease type III, nuclear, anticorps Ribonuclease 3, anticorps ribonuclease 3, anticorps drosha ribonuclease III, anticorps drosha, ribonuclease type III, anticorps rnasen, anticorps Thicy_0885, anticorps Sinme_0866, anticorps Isova_2087, anticorps Sphch_0770, anticorps DROSHA, anticorps Drosha
- Sujet
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RNASEN is a ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, RNASEN/DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. RNASEN is also involved in pre-rRNA processing. RNASEN cleaves double-strand RNA and does not cleave single-strand RNA. RNASEN is involved in the formation of GW bodies.Members of the ribonuclease III superfamily of double-stranded (ds) RNA-specific endoribonucleases participate in diverse RNA maturation and decay pathways in eukaryotic and prokaryotic cells (Fortin et al., 2002 [PubMed 12191433]). The RNase III Drosha is the core nuclease that executes the initiation step of microRNA (miRNA) processing in the nucleus (Lee et al., 2003 [PubMed 14508493]).[supplied by OMIM].
Alias Symbols: DROSHA, ETOHI2, HSA242976, RANSE3L, RN3, RNASE3L, RNASEN
Protein Interaction Partner: DDX5, HNRNPUL2, KLHL12, YLPM1, ZCCHC8, DGCR8, SKIV2L2, U2SURP, KHDRBS1, CARM1, RBM14, PDCD6, THRAP3, PPFIA1, SRPK1, PKP2, MEN1, LGALS3BP, HNRNPAB, WWOX, BMI1, SRPK2, ZNF512B, UBC, CUL3, PSMA1, BCL6, SP1,
Protein Size: 1374 - Poids moléculaire
- 159 kDa
- ID gène
- 29102
- NCBI Accession
- NM_013235, NP_037367
- UniProt
- Q9NRR4
- Pathways
- Regulatory RNA Pathways
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