REST anticorps (Middle Region)

N° du produit ABIN2780696

Détail du produit anti-REST anticorps

Antigène: REST (RE1-Silencing Transcription Factor (REST))

Épitope: Middle Region

Reactivité: Humain, Rat, Souris, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp REST est non-conjugé

Application: Western Blotting (WB)

Séquence: ANMGMALTND MYDLHELSKA ELAAPQLIML ANVALTGEAS GSCCDYLVGE

Homologie: Cow: 86%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 92%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against Rest. It was validated on Western Blot.

Purification: Affinity Purified

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 1082 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur REST

Antigène: REST (RE1-Silencing Transcription Factor (REST))

Autre désignation: Rest (REST Produits)

Synonymes: anticorps NRSF, anticorps XBR, anticorps 2610008J04Rik, anticorps AA407358, anticorps xbr, anticorps nrsf, anticorps rest, anticorps resta, anticorps REST, anticorps RE1 silencing transcription factor, anticorps RE1-silencing transcription factor, anticorps RE1-silencing transcription factor S homeolog, anticorps REST, anticorps Rest, anticorps rest.S, anticorps rest, anticorps LOC615792

Sujet: Rest is a transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Rest restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Rest mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier.
Alias Symbols: 2610008J04Rik, AA407358, MGC150099, NRSF
Protein Interaction Partner: L3mbtl2, Htt, Nanog, Sp3, Ewsr1, Nr0b1, Syt4, Calb1, Scn2a1, Bdnf, Ascl1,
Protein Size: 1082

Poids moléculaire: 118 kDa

ID gène: 19712

NCBI Accession: NM_011263, NP_035393

UniProt: Q8VIG1

Pathways: Negative Regulation of Hormone Secretion, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Chromatin Binding, Positive Regulation of Endopeptidase Activity