SENP6 anticorps (C-Term)
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- Antigène Voir toutes SENP6 Anticorps
- SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))
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Épitope
- C-Term
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Reactivité
- Humain, Souris, Rat, Boeuf (Vache), Cheval, Chien, Porc, Lapin
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp SENP6 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- LAVVCFPGLE KPKYEPNPHY HENAVMQKTP SAEDSCVSSA SEMGACSQNS
- Homologie
- Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%
- Attributs du produit
- This is a rabbit polyclonal antibody against Senp6. It was validated on Western Blot.
- Purification
- Affinity Purified
- Top Product
- Discover our top product SENP6 Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 1132 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))
- Autre désignation
- Senp6 (SENP6 Produits)
- Synonymes
- anticorps SSP1, anticorps SUSP1, anticorps 2810017C20Rik, anticorps E130319N12Rik, anticorps Susp1, anticorps mKIAA0797, anticorps fc83h02, anticorps im:7148342, anticorps wu:fc83h02, anticorps zgc:171230, anticorps SUMO1/sentrin specific peptidase 6, anticorps SUMO/sentrin specific peptidase 6, anticorps SUMO1/sentrin specific peptidase 6a, anticorps SENP6, anticorps Senp6, anticorps senp6a
- Sujet
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Senp6 is a protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Senp6 rocesses preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Senp6 deconjugates SUMO1 from RXRA, leading to transcriptional activation. Senp6 is involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Senp6 desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation and desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.
Alias Symbols: 2810017C20Rik, E130319N12Rik, MGC38009, Susp1, mKIAA0797
Protein Interaction Partner: Sumo3, Ikbkg,
Protein Size: 1132 - Poids moléculaire
- 127 kDa
- ID gène
- 215351
- NCBI Accession
- NM_146003, NP_666115
- UniProt
- Q6P7W0
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