ERCC8 anticorps (Middle Region)
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- Antigène Voir toutes ERCC8 Anticorps
- ERCC8 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8 (ERCC8))
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Épitope
- Middle Region
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Reactivité
- Humain, Souris, Rat, Chien, Lapin, Cheval, Boeuf (Vache), Porc, Cobaye
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp ERCC8 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- VRRASGCLIT LDQHNGKKSQ AVESANTAHN GKVNGLCFTS DGLHLLTVGT
- Homologie
- Cow: 93%, Dog: 100%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 93%, Rat: 100%
- Attributs du produit
- This is a rabbit polyclonal antibody against ERCC8. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the middle region of human ERCC8
- Top Product
- Discover our top product ERCC8 Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 396 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- ERCC8 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8 (ERCC8))
- Autre désignation
- ERCC8 (ERCC8 Produits)
- Synonymes
- anticorps zgc:103550, anticorps CKN1, anticorps CSA, anticorps UVSS2, anticorps Ckn1, anticorps 2410022P04Rik, anticorps 2810431L23Rik, anticorps 4631412O06Rik, anticorps B130065P18Rik, anticorps Csa, anticorps excision repair cross-complementation group 8, anticorps ERCC excision repair 8, CSA ubiquitin ligase complex subunit, anticorps excision repaiross-complementing rodent repair deficiency, complementation group 8, anticorps ercc8, anticorps ERCC8, anticorps Ercc8
- Sujet
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ERCC8 is a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS).This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes.
Alias Symbols: CKN1, CSA
Protein Interaction Partner: CUL4A, CUL4B, DDB1, RUVBL2, ZNF24, PCNA, H1F0, ERCC6, UVSSA, DDA1, RFWD2, COPS4, COPS6, COPS3, TOP1, TP53, SSBP1, OGG1, MDM2, GTF2H2, CUL5, GPS1, DDB2, COPS2, COPS7A, COPS5, COPS8, RBX1, POLR2A, HMGN1, EP300, UBC, CSNK2B, XAB2, UQCRQ, CBR1,
Protein Size: 396 - Poids moléculaire
- 44 kDa
- ID gène
- 1161
- NCBI Accession
- NM_000082, NP_000073
- UniProt
- Q13216
- Pathways
- Réparation de l'ADN, Positive Regulation of Response to DNA Damage Stimulus
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