PRNP anticorps (Middle Region)
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- Antigène Voir toutes PRNP Anticorps
- PRNP (Prion Protein (PRNP))
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Épitope
- Middle Region
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Reactivité
- Humain, Rat, Boeuf (Vache), Mouton, Chien, Chévre
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp PRNP est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Séquence
- GGGTHNQWNK PSKPKTNLKH VAGAAAAGAV VGGLGGYMLG SAMSRPMIHF
- Homologie
- Cow: 100%, Dog: 100%, Goat: 100%, Human: 100%, Rat: 100%, Sheep: 100%
- Attributs du produit
- This is a rabbit polyclonal antibody against Prnp. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the middle region of Mouse Prnp
- Top Product
- Discover our top product PRNP Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeat freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- PRNP (Prion Protein (PRNP))
- Autre désignation
- Prnp (PRNP Produits)
- Synonymes
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anticorps ASCR, anticorps AltPrP, anticorps CD230, anticorps CJD, anticorps GSS, anticorps KURU, anticorps PRIP, anticorps PrP, anticorps PrP27-30, anticorps PrP33-35C, anticorps PrPc, anticorps p27-30, anticorps Prn, anticorps Prn-p, anticorps prp, anticorps cjd, anticorps prion, anticorps prp(c), anticorps MGC84114, anticorps PRP, anticorps PRPC, anticorps Prp, anticorps SIP, anticorps PRNP, anticorps AA960666, anticorps AI325101, anticorps PrP
, anticorps PrPC, anticorps PrPSc, anticorps Prn-i, anticorps Sinc, anticorps prP27-30, anticorps prP33-35C, anticorps PrP-1, anticorps PrP1, anticorps prnprs1, anticorps stPrP-1, anticorps zgc:123004, anticorps prion protein, anticorps prion protein S homeolog, anticorps prion protein b, anticorps PRNP, anticorps Prnp, anticorps prnp.S, anticorps prnpb - Sujet
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Prnp may play a role in neuronal development and synaptic plasticity, may be required for neuronal myelin sheath maintenance and may play a role in iron uptake and iron homeostasis. Prnp is a soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. It also provides Cu2+ or ZN2+ for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains.
Alias Symbols: AA960666, AI325101, CD230, PrP, PrP, PrPC, PrPSc, Prn-i, Prn-p, Sinc, prP27-30, prP33-35C
Protein Interaction Partner: Dpp6, Eri3, Syn1, Grb2, Opcml, Lsamp, Ntm, Atp1a3, Igsf8, Cadm3, Clstn1, Pde10a, Adam23, Ywhaz, Ywhae, Stxbp1, Plp1, P4hb, Ncam2, Ncam1, Mog, Mbp, Mag, L1cam, Hspa5, Gnb1, Sparcl1, Dnm1, Dpysl2, Cntn1, Clu, Atp2b2, Atp1b1, Atp1a1, App, Apoe, Aplp2, Apbb1,
Protein Size: 254 - Poids moléculaire
- 28 kDa
- ID gène
- 19122
- NCBI Accession
- NM_011170, NP_035300
- UniProt
- P04925
- Pathways
- Transition Metal Ion Homeostasis, Activated T Cell Proliferation
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