JMY anticorps (N-Term)

N° du produit ABIN2789961

Détail du produit anti-JMY anticorps

Antigène: JMY (Junction Mediating and Regulatory Protein, P53 Cofactor (JMY))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp JMY est non-conjugé

Application: Western Blotting (WB)

Séquence: VFIVAWNEIE GKFAITCHNR TAQRQRSGSR EQAGARGGAE AGGAASDGSR

Homologie: Cow: 86%, Guinea Pig: 93%, Human: 100%, Mouse: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against JMY. It was validated on Western Blot.

Purification: Affinity Purified

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 712 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur JMY

Antigène: JMY (Junction Mediating and Regulatory Protein, P53 Cofactor (JMY))

Autre désignation: JMY (JMY Produits)

Synonymes: anticorps WHDC1L3, anticorps junction mediating and regulatory protein, p53 cofactor, anticorps junction-mediating and regulatory protein, anticorps JMY, anticorps jmy, anticorps Jmy

Sujet: JMY acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, JMY acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. JMY increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, JMY acts as a nucleation-promoting factor for both branched and unbranched actin filaments. JMY activates the Arp2/3 complex to induce branched actin filament networks. JMY also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. JMY contributes to cell motility by controlling actin dynamics. JMY may promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location.
Alias Symbols: FLJ37870, MGC163496, WHDC1L3
Protein Interaction Partner: CCDC136, UBC, EP300, MDM2, E2F4, E2F3, E2F2, E2F1,
Protein Size: 712

Poids moléculaire: 82 kDa

ID gène: 133746

NCBI Accession: NM_152405, NP_689618

UniProt: Q8N9B5

Pathways: Regulation of Actin Filament Polymerization