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JMY anticorps (N-Term)

JMY Reactivité: Humain, Souris, Rat, Boeuf (Vache), Cobaye WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2789961
  • Antigène Voir toutes JMY Anticorps
    JMY (Junction Mediating and Regulatory Protein, P53 Cofactor (JMY))
    Épitope
    • 8
    • 7
    • 6
    • 5
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 44
    • 16
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain, Souris, Rat, Boeuf (Vache), Cobaye
    Hôte
    • 41
    • 4
    Lapin
    Clonalité
    • 41
    • 3
    Polyclonal
    Conjugué
    • 24
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp JMY est non-conjugé
    Application
    • 30
    • 28
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Séquence
    VFIVAWNEIE GKFAITCHNR TAQRQRSGSR EQAGARGGAE AGGAASDGSR
    Homologie
    Cow: 86%, Guinea Pig: 93%, Human: 100%, Mouse: 100%, Rat: 100%
    Attributs du produit
    This is a rabbit polyclonal antibody against JMY. It was validated on Western Blot.
    Purification
    Affinity Purified
    Top Product
    Discover our top product JMY Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 712 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Antigène
    JMY (Junction Mediating and Regulatory Protein, P53 Cofactor (JMY))
    Autre désignation
    JMY (JMY Produits)
    Synonymes
    anticorps WHDC1L3, anticorps junction mediating and regulatory protein, p53 cofactor, anticorps junction-mediating and regulatory protein, anticorps JMY, anticorps jmy, anticorps Jmy
    Sujet
    JMY acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, JMY acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. JMY increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, JMY acts as a nucleation-promoting factor for both branched and unbranched actin filaments. JMY activates the Arp2/3 complex to induce branched actin filament networks. JMY also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. JMY contributes to cell motility by controlling actin dynamics. JMY may promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location.
    Alias Symbols: FLJ37870, MGC163496, WHDC1L3
    Protein Interaction Partner: CCDC136, UBC, EP300, MDM2, E2F4, E2F3, E2F2, E2F1,
    Protein Size: 712
    Poids moléculaire
    82 kDa
    ID gène
    133746
    NCBI Accession
    NM_152405, NP_689618
    UniProt
    Q8N9B5
    Pathways
    Regulation of Actin Filament Polymerization
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