CDC42 anticorps (N-Term)

N° du produit ABIN2792111

Cet anticorps anti-CDC42 est un anticorps Lapin Polyclonal détectant CDC42 dans WB et IHC. Adapté pour Chien et Lapin.

Aperçu rapide pour CDC42 anticorps (N-Term) (ABIN2792111)

Antigène: CDC42 (Cell Division Cycle 42 (GTP Binding Protein, 25kDa) (CDC42))

Reactivité: Chien, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CDC42 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-CDC42 anticorps

Épitope: N-Term

Séquence: DNYAVTVMIG GEPYTLGLFD TAGQEDYDRL RPLSYPQTDV FLVCFSVVSP

Homologie: Dog: 100%, Rabbit: 100%

Attributs du produit: This is a rabbit polyclonal antibody against CDC42. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human CDC42

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 191 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur CDC42

Antigène: CDC42 (Cell Division Cycle 42 (GTP Binding Protein, 25kDa) (CDC42))

Autre désignation: CDC42

Sujet: CDC42 is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants.The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants.
Alias Symbols: CDC42Hs, G25K
Protein Interaction Partner: PARD6B, CDC42EP1, CDC42EP2, PAK2, UBC, TRAF2, PAK1, ARHGDIA, BIRC2, TNK2, TCEB2, EPRS, LARS, RUVBL1, NEK6, WIPF1, WASL, RIOK3, SSX2IP, DIAPH3, BAIAP2, PAK3, ZNF420, IQGAP1, RAP1A, WAS, TGFBR2, TGFBR1, ARHGEF6, LRRK2, FGD3, ARHGAP1, SH3RF3, BCAR1, USP6, EL
Protein Size: 191

Poids moléculaire: 21 kDa

ID gène: 998

NCBI Accession: NM_001791, NP_001782

UniProt: P60953

Pathways: Signalisation MAPK, Dynamique des Microtubules, Signalisation RTK, Signalisation WNT, TCR Signaling, EGFR Signaling Pathway, Regulation of Actin Filament Polymerization, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Maintenance of Protein Location, Skeletal Muscle Fiber Development, Signaling Events mediated by VEGFR1 and VEGFR2, EGFR Downregulation, VEGF Signaling