ERCC2 anticorps (N-Term)

N° du produit ABIN2792558

Détail du produit anti-ERCC2 anticorps

Antigène: ERCC2 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Cobaye, Boeuf (Vache), Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ERCC2 est non-conjugé

Application: Western Blotting (WB)

Séquence: KLNVDGLLVY FPYDYIYPEQ FSYMRELKRT LDAKGHGVLE MPSGTGKTVS

Réactivité croisée: Boeuf (Vache), Mouche des fruits (Drosophila melanogaster), Humain, Souris, Porc, Rat (Rattus)

Homologie: Cow: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against ERCC2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human ERCC2

Information d'application

Indications d'application: WB Suggested Anti-ERCC2 Antibody Titration: 0.2-1 µg/mL
ELISA Titer: 1:312500
Positive Control: Human Muscle.
Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 760 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur ERCC2

Antigène: ERCC2 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2))

Autre désignation: ERCC2 (ERCC2 Produits)

Synonymes: anticorps COFS2, anticorps EM9, anticorps TTD, anticorps XPD, anticorps AA407812, anticorps AU020867, anticorps AW240756, anticorps CXPD, anticorps Ercc-2, anticorps MGC89573, anticorps CG9433, anticorps DhR3, anticorps DhXPD, anticorps DmXPD, anticorps Dmel\\CG9433, anticorps ERCC2, anticorps XPD/ERCC2, anticorps l(2)SH2 2137, anticorps l(2)SH2137, anticorps xpd, anticorps zgc:56365, anticorps ERCC excision repair 2, TFIIH core complex helicase subunit, anticorps excision repair cross-complementing rodent repair deficiency, complementation group 2, anticorps excision repair cross-complementation group 2, anticorps Xeroderma pigmentosum D, anticorps ERCC2, anticorps Ercc2, anticorps ercc2, anticorps Xpd

Sujet: The nucleotide excision repair pathway is a mechanism to repair damage to DNA. ERCC2 is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. This protein has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: COFS2, EM9, MGC102762, MGC126218, MGC126219, TTD, XPD
Protein Interaction Partner: GTF2H2C_2, UBC, FAM96B, CIAO1, rev, CDK7, TP53, MMS19, ERCC3, UVSSA, RAD52, GTF2H1, MNAT1, CCNH, GTF2F1, PIDD1, GTF2H3, GTF2H2, AR, ERCC6, tat, ATF7IP, HERC5, ISG15, TRIM25, RAD51, ERCC5, ERCC2, CDK1,
Protein Size: 760

Poids moléculaire: 87 kDa

ID gène: 2068

NCBI Accession: NM_000400, NP_000391

UniProt: P18074

Pathways: Réparation de l'ADN