Exonuclease 1 anticorps (AA 31-130) (Alexa Fluor 594)
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- Antigène Voir toutes Exonuclease 1 (EXO1) Anticorps
- Exonuclease 1 (EXO1)
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Épitope
- AA 31-130
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Reactivité
- Humain, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp Exonuclease 1 est conjugé à/à la Alexa Fluor 594
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Application
- Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Réactivité croisée
- Humain, Souris
- Homologie
- Rat
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human Exonuclease 1
- Isotype
- IgG
- Top Product
- Discover our top product EXO1 Anticorps primaire
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- Indications d'application
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FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- Exonuclease 1 (EXO1)
- Autre désignation
- Exonuclease 1 (EXO1 Produits)
- Synonymes
- anticorps HEX1, anticorps hExoI, anticorps 5730442G03Rik, anticorps Msa, anticorps EXO1, anticorps exoi, anticorps fc16e04, anticorps wu:fc16e04, anticorps zgc:55521, anticorps exonuclease 1, anticorps hypothetical protein, anticorps exonuclease I Exo1, anticorps RNA exonuclease, anticorps exonuclease 1 S homeolog, anticorps EXO1, anticorps Y17G7B.12, anticorps SJAG_01832, anticorps PAS_chr1-1_0377, anticorps Exo1, anticorps exo1, anticorps exo1.S, anticorps LOC100338764
- Sujet
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Synonyms: exo1, EXO1_HUMAN, ExoI, Exonuclease 1, Exonuclease I, Exonuclease1, HEX1, hExo I, hExo1, hExoI, Rad2 nuclease family member homolog of S. cerevisiae exonuclease 1.
Background: Comparative evaluation of the expression patterns of the human and mouse genes, combined with previous biochemical and yeast genetic studies, indicate that the Exo1 (Exonuclease I) proteins are important contributors to chromosome processing during mammalian DNA repair and recombination. In mice, the Exo1 gene maps to distal chromosome 1, consistent with the recent mapping of the orthologous human HEX1/EXO1 gene to chromosome 1q43. Exo1 is expressed prominently in testis, an area of active homologous recombination, and spleen, a prominent lymphoid tissue. In both mammalian and yeast systems, Exo1 is a 5'-3' double stranded DNA exonuclease that has previously been implicated in DNA mismatch repair (MMR). The MMR system ensures genome integrity by removing mispaired and unpaired bases that originate during replication. In humans, Exo1 interacts with MSH2 and MLH1 and has been proposed to be a redundant exonuclease in MMR. In both mammalian and yeast systems, Exo1 plays a structural role in MMR and stabilizes multiprotein complexes containing a number of MMR proteins.
- ID gène
- 9156
- Pathways
- Réparation de l'ADN, Production of Molecular Mediator of Immune Response
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