Glucocorticoid Receptor anticorps (N-Term)
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- Antigène Voir toutes Glucocorticoid Receptor (NR3C1) Anticorps
- Glucocorticoid Receptor (NR3C1) (Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1))
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Épitope
- N-Term
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp Glucocorticoid Receptor est non-conjugé
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Application
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Immunocytochemistry (ICC)
- Réactivité croisée
- Humain, Souris, Rat
- Attributs du produit
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Rabbit Polyclonal antibody to Glucocorticoid receptor (nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor))
Glucocorticoid receptor antibody - Purification
- Purified by antigen-affinity chromatography.
- Classe de qualité
- KO Validated
- Immunogène
- Recombinant protein encompassing a sequence within the N-terminus region of human Glucocorticoid Receptor. The exact sequence is proprietary.
- Isotype
- IgG
- Top Product
- Discover our top product NR3C1 Anticorps primaire
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- Indications d'application
- WB: 1:500-1:3000. IHC-P: 1:100-1:1000. IP: 1:500-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
- Commentaires
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Positive Control: A431 , mouse heart , rat heart , HeLa
Validation: KO/KD
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal
- Agent conservateur
- Thimerosal (Merthiolate)
- Précaution d'utilisation
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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Systems level-based RNAi screening by high content analysis identifies UBR5 as a regulator of estrogen receptor-α protein levels and activity." dans: Oncogene, Vol. 34, Issue 2, pp. 154-64, (2015) (PubMed).
: "Coactivators enable glucocorticoid receptor recruitment to fine-tune estrogen receptor transcriptional responses." dans: Nucleic acids research, Vol. 41, Issue 7, pp. 4036-48, (2013) (PubMed).
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Systems level-based RNAi screening by high content analysis identifies UBR5 as a regulator of estrogen receptor-α protein levels and activity." dans: Oncogene, Vol. 34, Issue 2, pp. 154-64, (2015) (PubMed).
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- Antigène
- Glucocorticoid Receptor (NR3C1) (Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1))
- Autre désignation
- nuclear receptor subfamily 3 group C member 1 (NR3C1 Produits)
- Synonymes
- anticorps GR, anticorps gcr, anticorps grl, anticorps xGR, anticorps gccr, anticorps gr, anticorps zgc:113038, anticorps NR3C1, anticorps GCL, anticorps LOC100302444, anticorps Gcr, anticorps Grl, anticorps Grl-1, anticorps Grl1, anticorps GRL, anticorps GCCR, anticorps GCR, anticorps NO, anticorps GR-A, anticorps nr3c1, anticorps nuclear receptor subfamily 3 group C member 1, anticorps nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor), anticorps nuclear receptor subfamily 3, group C, member 1, anticorps glucocorticoid receptor, anticorps NR3C1, anticorps nr3c1, anticorps LOC100302444, anticorps Nr3c1
- Sujet
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The protein encoded by this gene is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. This protein can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Mutations in this gene are a cause of glucocorticoid resistance, or cortisol, resistance. Alternate splicing, the use of at least three different promoters, and alternate translation initiation sites result in several transcript variants encoding the same protein or different isoforms, but the full-length nature of some variants has not been determined.
Cellular Localization: Cytoplasm , Nucleus - Poids moléculaire
- 86 kDa
- ID gène
- 2908
- UniProt
- P04150
- Pathways
- Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Regulation of Muscle Cell Differentiation, Regulation of Carbohydrate Metabolic Process
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