Glucocorticoid Receptor anticorps (Ser226, Ser234, Ser246)

N° du produit ABIN7180016

Détail du produit anti-Glucocorticoid Receptor anticorps

Antigène: Glucocorticoid Receptor (NR3C1) (Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1))

Épitope: Ser226, Ser234, Ser246

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Glucocorticoid Receptor est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Réactivité croisée: Humain, Souris, Rat

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized non-phosphopeptide derived from Human GR around the phosphorylation site of serine 226/234/246 (L-L-S-P-L).

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:3000, IHC:1:50-1:100,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur Glucocorticoid Receptor

Antigène: Glucocorticoid Receptor (NR3C1) (Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1))

Autre désignation: NR3C1 (NR3C1 Produits)

Synonymes: anticorps GR, anticorps gcr, anticorps grl, anticorps xGR, anticorps gccr, anticorps gr, anticorps zgc:113038, anticorps NR3C1, anticorps GCL, anticorps LOC100302444, anticorps Gcr, anticorps Grl, anticorps Grl-1, anticorps Grl1, anticorps GRL, anticorps GCCR, anticorps GCR, anticorps NO, anticorps GR-A, anticorps nr3c1, anticorps nuclear receptor subfamily 3 group C member 1, anticorps nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor), anticorps nuclear receptor subfamily 3, group C, member 1, anticorps glucocorticoid receptor, anticorps NR3C1, anticorps nr3c1, anticorps LOC100302444, anticorps Nr3c1

Sujet:

Background: Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic genes expression.

Kyung Jin Kwak, J. Exp. Bot., Nov 2005, 56: 3007 - 3016.
Maite de Llanos, Hum. Reprod., Jan 2005, 20: 216 - 220.
M. Lynch, Mol. Hum. Reprod., Jul 2005, 11: 507 - 512.
Valeriya P. Makarenkova, J. Immunol., Feb 2006, 176: 2085 - 2094.

Aliases: GCCR antibody, GCR antibody, GCR_HUMAN antibody, GCRST antibody, glucocorticoid nuclear receptor variant 1 antibody, Glucocorticoid receptor antibody, GR antibody, GRL antibody, Grl1 antibody, nr3c1 antibody, Nuclear receptor subfamily 3 group C member 1 antibody, nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) antibody

UniProt: P04150

Pathways: Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Regulation of Muscle Cell Differentiation, Regulation of Carbohydrate Metabolic Process