HLA-DQA1 anticorps (AA 24-216)

N° du produit ABIN3023103

Détail du produit anti-HLA-DQA1 anticorps

Antigène: HLA-DQA1 (Major Histocompatibility Complex, Class II, DQ alpha 1 (HLA-DQA1))

Épitope: AA 24-216

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HLA-DQA1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: EDIVADHVAS CGVNLYQFYG PSGQYTHEFD GDEQFYVDLE RKETAWRWPE FSKFGGFDPQ GALRNMAVAK HNLNIMIKRY NSTAATNEVP EVTVFSKSPV TLGQPNTLIC LVDNIFPPVV NITWLSNGQS VTEGVSETSF LSKSDHSFFK ISYLTFLPSA DEIYDCKVEH WGLDQPLLKH WEPEIPAPMS ELT

Réactivité croisée: Humain, Souris

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 24-216 of human HLA-DQA1 (NP_002113.2).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze / thaw cycles

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur HLA-DQA1

Antigène: HLA-DQA1 (Major Histocompatibility Complex, Class II, DQ alpha 1 (HLA-DQA1))

Autre désignation: HLA-DQA1 (HLA-DQA1 Produits)

Synonymes: anticorps CD, anticorps CELIAC1, anticorps DQ-A1, anticorps GSE, anticorps HLA-DQA, anticorps BoLA-DQA, anticorps hla-dqa1, anticorps major histocompatibility complex, class II, DQ alpha 1, anticorps major histocompatibility complex, class II, DQ alpha, type 1, anticorps major histocompatibility complex, class II, DQ alpha 1 L homeolog, anticorps HLA-DQA1, anticorps BOLA-DQA1, anticorps hla-dqa1.L

Sujet: HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons, exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.,HLA-DQA1,CELIAC1,DQ-A1,HLA-DQA,CD,GSE,class II,HLA-DQA1

Poids moléculaire: 27 kDa

ID gène: 3117

UniProt: P01909

Pathways: TCR Signaling, Cancer Immune Checkpoints