HLA-DQA1 anticorps (N-Term)

N° du produit ABIN656108

Détail du produit anti-HLA-DQA1 anticorps

Antigène: HLA-DQA1 (Major Histocompatibility Complex, Class II, DQ alpha 1 (HLA-DQA1))

Épitope: AA 39-66, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HLA-DQA1 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This HLA-DQA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-66 amino acids from the N-terminal region of human HLA-DQA1.

Clone: RB32210

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:1000. WB: 1:1000. FC: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Détails sur HLA-DQA1

Antigène: HLA-DQA1 (Major Histocompatibility Complex, Class II, DQ alpha 1 (HLA-DQA1))

Autre désignation: HLA-DQA1 (HLA-DQA1 Produits)

Synonymes: anticorps CD, anticorps CELIAC1, anticorps DQ-A1, anticorps GSE, anticorps HLA-DQA, anticorps BoLA-DQA, anticorps hla-dqa1, anticorps major histocompatibility complex, class II, DQ alpha 1, anticorps major histocompatibility complex, class II, DQ alpha, type 1, anticorps major histocompatibility complex, class II, DQ alpha 1 L homeolog, anticorps HLA-DQA1, anticorps BOLA-DQA1, anticorps hla-dqa1.L

Sujet: HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons, exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.

Poids moléculaire: 27805

ID gène: 3117

NCBI Accession: NP_002113

UniProt: P01909

Pathways: TCR Signaling, Cancer Immune Checkpoints