HLA-DQA1 anticorps (AA 39-66)

N° du produit ABIN3031680

Détail du produit anti-HLA-DQA1 anticorps

Antigène: HLA-DQA1 (Major Histocompatibility Complex, Class II, DQ alpha 1 (HLA-DQA1))

Épitope: AA 39-66

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HLA-DQA1 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Purification: Antigen affinity purified

Immunogène: A portion of amino acids 39-66 from the human protein was used as the immunogen for this HLA-DQA1 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the HLA-DQA1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Flow Cytometry: 1:10-1:50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the HLA-DQA1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur HLA-DQA1

Antigène: HLA-DQA1 (Major Histocompatibility Complex, Class II, DQ alpha 1 (HLA-DQA1))

Autre désignation: HLA-DQA1 (HLA-DQA1 Produits)

Synonymes: anticorps CD, anticorps CELIAC1, anticorps DQ-A1, anticorps GSE, anticorps HLA-DQA, anticorps BoLA-DQA, anticorps hla-dqa1, anticorps major histocompatibility complex, class II, DQ alpha 1, anticorps major histocompatibility complex, class II, DQ alpha, type 1, anticorps major histocompatibility complex, class II, DQ alpha 1 L homeolog, anticorps HLA-DQA1, anticorps BOLA-DQA1, anticorps hla-dqa1.L

Sujet: HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons, exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.

UniProt: P01909

Pathways: TCR Signaling, Cancer Immune Checkpoints