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Retinoblastoma 1 anticorps (pSer811)

Name: Retinoblastoma 1 anticorps (pSer811)
Brand: antibodies-online
SKU: ABIN3023610
Price: 879.42 EUR
Availability: InStock

RB1 Reactivité: Humain WB Hôte: Lapin Polyclonal unconjugated

Western Blotting (WB) image for anti-Retinoblastoma 1 (RB1) (pSer811) antibody (ABIN3023610) (Retinoblastoma 1 anticorps (pSer811))

Immunofluorescence analysis of U2OS cells using Phospho-Rb-S811 antibody. (Retinoblastoma 1 anticorps (pSer811))

Western blot analysis of extracts of 293 and HeLa cells, using Phospho-Rb-S811 antibody. (Retinoblastoma 1 anticorps (pSer811))

MiR-188 arrests cell cycle at G1/S transition through negative regulation of Rb-E2F axis. (Retinoblastoma 1 anticorps (pSer811))

MiR-188 suppresses tumor initiation and progressionin vivo. (Retinoblastoma 1 anticorps (pSer811))

6 images

(1 reference)

N° du produit ABIN3023610

Fiche de données

Antigène Voir toutes Retinoblastoma 1 (RB1) Anticorps

Retinoblastoma 1 (RB1)
Épitope
36

29

26

25

23

21

19

15

11

10

10

7

6

6

4

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
pSer811
Reactivité
280

119

101

6

4

4

4

3

3

3

2

1

1

1
Humain
Hôte
247

36
Lapin
Anticorps secondaires appropriés
Clonalité
238

45
Polyclonal
Conjugué
134

19

17

16

11

10

8

8

6

6

6

6

6

6

6

6

6

1

1

1

1

1

1
Cet anticorp Retinoblastoma 1 est non-conjugé
Application
212

121

110

80

79

40

33

28

28

20

16

8

7

6

6

6

4

2

1
Western Blotting (WB)

Séquence

LKSPY

Réactivité croisée

Humain

Attributs du produit

Phosphorylated Antibodies

Purification

Affinity purification

Immunogène

A synthetic phosphorylated peptide around S811 of human RB (NP_000312.2).

Isotype

IgG

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Indications d'application

WB,1:1000 - 1:2000

Restrictions

For Research Use only
Format

Liquid

Buffer

PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur

Sodium azide

Précaution d'utilisation

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation

Avoid freeze / thaw cycles

Stock

-20 °C

Stockage commentaire

Store at -20°C. Avoid freeze / thaw cycles.
Wu, Lv, He, Zhang, Mei, Cui, Huang, Xie, Xu, Zhang: "MicroRNA-188 suppresses G1/S transition by targeting multiple cyclin/CDK complexes." dans: Cell communication and signaling : CCS, Vol. 12, pp. 66, (2015) (PubMed).
Antigène

Retinoblastoma 1 (RB1)

Autre désignation

RB1 (RB1 Produits)

Synonymes

anticorps OSRC, anticorps RB, anticorps p105-Rb, anticorps pRb, anticorps pp110, anticorps Rb, anticorps Rb-1, anticorps P105-RB, anticorps PP110, anticorps RB11, anticorps zgc:154147, anticorps RB transcriptional corepressor 1, anticorps RB transcriptional corepressor like 1, anticorps retinoblastoma 1, anticorps RB1, anticorps RBL1, anticorps Rb1, anticorps rb1

Sujet

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.,OSRC,PPP1R130,RB,p105-Rb,pRb,pp110,RB1,Rb,Epigenetics & Nuclear Signaling,Transcription Factors,DNA Damage & Repair,Cancer,Tumor suppressors,Cell Biology & Developmental Biology,Cell Cycle,Cell cycle inhibitors,G1/S Checkpoint,Protein phosphorylation,RB1

Poids moléculaire

106 kDa

ID gène

5925

UniProt

P06400

Pathways

Cycle Cellulaire, Intracellular Steroid Hormone Receptor Signaling Pathway, Mitotic G1-G1/S Phases, DNA Replication, Maintenance of Protein Location, Synthesis of DNA, Autophagy