RAGE anticorps (Middle Region)
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- Antigène Voir toutes RAGE (AGER) Anticorps
- RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))
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Épitope
- Middle Region
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp RAGE est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Purification
- Antigen affinity
- Immunogène
- An amino acid sequence from the middle region of human RAGE (KEQTRRHPETGLFTLQSEL) was used as the immunogen for this RAGE antibody.
- Isotype
- IgG
- Top Product
- Discover our top product AGER Anticorps primaire
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- Indications d'application
- The stated application concentrations are suggested starting amounts. Titration of the RAGE antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,IHC (Frozen): 0.5-1 μg/mL
- Restrictions
- For Research Use only
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- Buffer
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
- Stock
- -20 °C
- Stockage commentaire
- After reconstitution, the RAGE antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
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- Antigène
- RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))
- Autre désignation
- RAGE (AGER Produits)
- Synonymes
- anticorps RAGE, anticorps AGER, anticorps advanced glycosylation end-product specific receptor, anticorps advanced glycosylation end product-specific receptor, anticorps MAPK/MAK/MRK overlapping kinase, anticorps AGER, anticorps Ager, anticorps LOC719012
- Sujet
- The receptor for advanced glycation end products(RAGE) is a multi-ligand member of the immunoglobulin superfamily of cell surface molecules. It interacts with distinct molecules implicated in homeostasis, development and inflammation, and certain diseases such as diabetes and Alzheimers disease. RAGE is also a central cell surface receptor for amphoterin and EN-RAGE. RAGE is associated with sustained NF-kappaB activation in the diabetic microenvironment and has a central role in sensory neuronal dysfunction. Moreover, RAGE propagates cellular dysfunction in several inflammatory disorders and diabetes, and it also functions as an endothelial adhesion receptor promoting leukocyte recruitment.
- UniProt
- Q15109
- Pathways
- Carbohydrate Homeostasis, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, S100 Proteins
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