E2F4 anticorps (Middle Region)

N° du produit ABIN3030790

Détail du produit anti-E2F4 anticorps

Antigène: E2F4 (E2F Transcription Factor 4, P107/p130-Binding (E2F4))

Épitope: Middle Region

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp E2F4 est non-conjugé

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogène: An amino acid sequence from the middle region of human E2F4 (LPKPALAQSQEASRPN) was used as the immunogen for this E2F4 antibody.

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the E2F4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the E2F4 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur E2F4

Antigène: E2F4 (E2F Transcription Factor 4, P107/p130-Binding (E2F4))

Autre désignation: E2F4 (E2F4 Produits)

Synonymes: anticorps E2F-4, anticorps 2010111M04Rik, anticorps AI427446, anticorps E2F4, anticorps e2f-4, anticorps fb72f07, anticorps wu:fb72f07, anticorps wu:fe05f06, anticorps zgc:63815, anticorps E2F transcription factor 4, anticorps E2F transcription factor 4 S homeolog, anticorps E2F4, anticorps E2f4, anticorps e2f4.S, anticorps e2f4

Sujet: Transcription factor E2F4 is a protein that in humans is encoded by the E2F4 gene. The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins(DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer.

UniProt: Q16254

Pathways: Cycle Cellulaire, Mitotic G1-G1/S Phases, Regulation of Cell Size