NME1 anticorps (C-Term)

N° du produit ABIN3032024

Détail du produit anti-NME1 anticorps

Antigène: NME1 (Non-Metastatic Cells 1, Protein (NM23A) Expressed in (NME1))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NME1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Purification: Antigen affinity

Immunogène: An amino acid sequence from the C-terminus of human NM23 (EELVDYTSCAQNWIYE) was used as the immunogen for this NM23 antibody.

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the NM23 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,Immunocytochemistry: 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the NM23 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur NME1

Antigène: NME1 (Non-Metastatic Cells 1, Protein (NM23A) Expressed in (NME1))

Autre désignation: NM23 (NME1 Produits)

Synonymes: anticorps AWD, anticorps GAAD, anticorps NB, anticorps NBS, anticorps NDKA, anticorps NDPK-A, anticorps NDPKA, anticorps NM23, anticorps NM23-H1, anticorps AL024257, anticorps NM23-M1, anticorps NM23A, anticorps NDPK-Z1, anticorps NM23-B, anticorps NM23-Z1, anticorps ndpkz1, anticorps nm23b, anticorps nme1, anticorps nme2, anticorps nme2b1, anticorps NME1, anticorps NME1-NME2, anticorps NM23-C1, anticorps ndpk-b, anticorps ndpkb, anticorps nm23-h2, anticorps nm23ndk, anticorps puf, anticorps NBR-A, anticorps NBR-B, anticorps NME1-1, anticorps nm23ndk-a, anticorps NDK I, anticorps NDPK I, anticorps T30A10.80, anticorps T30A10_80, anticorps NDP kinase I, anticorps NME/NM23 nucleoside diphosphate kinase 1, anticorps NME/NM23 nucleoside diphosphate kinase 2b, tandem duplicate 1, anticorps non-metastatic cells 1, protein (NM23A) expressed in, anticorps NME/NM23 nucleoside diphosphate kinase 2 S homeolog, anticorps NME/NM23 nucleoside diphosphate kinase 2 L homeolog, anticorps nucleoside diphosphate kinase, anticorps nucleoside diphosphate kinase 1, anticorps NME1, anticorps Nme1, anticorps nme2b.1, anticorps nme2.S, anticorps nme2.L, anticorps LOC547870, anticorps NDPK1, anticorps LOC107790563

Sujet: NME1 (NME/NM23 nucleoside diphosphate kinase 1), also called non-Metastatic protein 23 (NM23), is an enzyme that in humans encoded by the NME1 gene. The promoters of the mouse and human NME1 genes, like those of other NME genes, contain several binding sites for AP2, NF1, Sp1, LEF1, and response elements to glucocorticoid receptors. Immunofluorescence microscopy demonstrated colocalization of NME1 in nuclei of B cells expressing EBNA3C. Expression of EBNA3C reversed the ability of NME1 to inhibit migration of BL and breast carcinoma cells. NME1/NM23 bound SET and was released from inhibition by GZMA cleavage of SET. After GZMA loading or cytotoxic T lymphocyte attack, SET and NM23 translocated to the nucleus and SET was degraded, allowing NM23 to nick chromosomal DNA. Using a Drosophila model system,Dammai et al.(2003) showed that the Drosophila NME1 homolog, AWD, regulates trachea cell motility by modulating FGFR levels through a dynamin -mediated pathway.

UniProt: P15531

Pathways: Apoptose, Nucleotide Phosphorylation, Carbohydrate Homeostasis, Ribonucleoside Biosynthetic Process