SLC2A4
Reactivité: Humain, Souris, Rat
IHC
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
The stated application concentrations are suggested starting points. Titration of the GLUT4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL
Restrictions
For Research Use only
Buffer
0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
Stock
-20 °C
Stockage commentaire
After reconstitution, the GLUT4 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Antigène
GLUT4 (SLC2A4)
(Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 4 (SLC2A4))
anticorps GLUT4, anticorps Glut-4, anticorps Glut4, anticorps glut4, anticorps slc2a4, anticorps SLC2A4, anticorps solute carrier family 2 member 4, anticorps solute carrier family 2 (facilitated glucose transporter), member 4, anticorps solute carrier family 2 (facilitated glucose transporter), member 4 L homeolog, anticorps SLC2A4, anticorps Slc2a4, anticorps GLUT4, anticorps slc2a4.L
Sujet
Facilitated glucose transport by mammalian cells is not a property of a single protein but an activity associated with a family of structurally related proteins. Glucose transporter 4 is a insulin-responsive glucose transporter. It belongs to solute carrier family 2, member 1. Insulin alters the subcellular localization of GLUT4 vesicles in human muscle, and that this effect is impaired equally in insulin-resistant subjects with and without diabetes. A similar pattern of defects cause insulin resistance in human adipocytes. Human insulin resistance involves a defect in GLUT4 traffic and targeting leading to accumulation in a dense membrane compartment from which insulin is unable to recruit GLUT4 to the cell surface.