LKB1 anticorps (N-Term)

N° du produit ABIN303290

Détail du produit anti-LKB1 anticorps

Antigène: LKB1 (STK11) (serine/threonine Kinase 11 (STK11))

Épitope: N-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LKB1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody Recognises LKB1 / STK11.

Réactivité croisée (Details): Species reactivity (expected):Mouse.
Species reactivity (tested):Human.

Purification: Immunoaffinity Chromatography.

Immunogène: Synthetic peptide correponding to 15 Amino Acid peptide from near the amino terminus of Human LKB1/STK11.

Information d'application

Indications d'application: Western Blot. Immunohistochemistry on Paraffin Sections (5 μg/mL).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate Buffered Saline PBS containing 0.02 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer. Dilute only prior to immediate use.

Détails sur LKB1

Antigène: LKB1 (STK11) (serine/threonine Kinase 11 (STK11))

Autre désignation: STK11 (STK11 Produits)

Synonymes: anticorps pjs, anticorps LKB1, anticorps XEEK1, anticorps Stk11, anticorps PJS, anticorps hLKB1, anticorps AA408040, anticorps Lkb1, anticorps Par-4, anticorps R75140, anticorps mLKB1, anticorps wu:fj61a05, anticorps zgc:110180, anticorps xeek1, anticorps serine/threonine kinase 11, anticorps polarization-related protein LKB1, anticorps serine/threonine kinase 11 L homeolog, anticorps STK11, anticorps stk11, anticorps LOC662493, anticorps Stk11, anticorps stk11.L

Sujet: LKB1, a member of the serine/threonine kinase family, is a tumor suppressor. Physically associates with p53, it regulates specific p53 dependent apoptosis pathways. LKB1 protein is present in both the cytoplasm and nucleus of living cells and translocates to mitochondria during apoptosis. Restoring LKB1 activity into cancer cell lines defective for its expression results in a G1 cell cycle arrest. Mutations in LKB1 gene are associated with Peutz Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. LKB1 functions as a master upstream protein kinase, regulating AMPK related kinases as well as AMPK. In vitro, LKB1 has been observed to directly phosphorylate threonine 172 of AMPKa, an event that is correlated with activation of this kinase. LKB1 has also been found to play a role in chromatin remodeling, cell cycle arrest, Wnt signaling, cell polarity, and energy metabolism.Synonyms: LKB1, NY-REN-19, PJS, Renal carcinoma antigen NY-REN-19, Serine/threonine-protein kinase 11, Serine/threonine-protein kinase LKB1

ID gène: 6794

NCBI Accession: NP_000446

UniProt: Q15831

Pathways: AMPK Signaling, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, L'effet Warburg